The synthesis and screening of polymer libraries using a high throughput approach

Mizomoto, Hitoshi (2004) The synthesis and screening of polymer libraries using a high throughput approach. University of Southampton, Doctoral Thesis.

Record type: Thesis (Doctoral)

Abstract

This thesis describes the development of blood compatible polymer libraries and a variety of novel high throughput screening techniques.

6 polymer libraries, comprising of 446 polymers prepared by free radical polymerisation and 90 polymers made by functionalisation of polymer side chains, were prepared by a variety of combinatorial approaches. High throughput polymer synthesis, purification, and analysis were established using a 96-well plate format and microarray techniques.

Novel high throughput methods, for evaluating the wettability of polymer and their thermal properties were developed. Protein adsorption onto polymers and leucocyte depletion abilities were investigated to determine the relationship between the binding of blood components and polymers in order to improve the biocompatibilities of polymeric materials.

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