The renin-angiotensin system and its role in ovine cardiovascular control and growth following early gestation and early postnatal nutrient restriction
The renin-angiotensin system and its role in ovine cardiovascular control and growth following early gestation and early postnatal nutrient restriction
The aim of this thesis was to investigate, in terms of RAS-mediated cardiovascular control, the concept that the prenatal predictive adaptive responses to undernutrition may establish a phenotype which determines how the individual responds to the postnatal environment.
Welsh Mountain ewes received 100 % (C) or 50 % (U) of total nutrient requirements from 1-31 days gestational age (dGA), and 100 % thereafter. At 70 dGA a subset of fetuses were removed for subsequent molecular and histological analysis. Offspring were fed ad libitum (CC & UC) or at a level that reduced body weight to 85 % of individual target weight from 12 to 25 weeks postnatal age and ad libitum thereafter (CU & UU).
UC males, but not females, had increased early postnatal growth, increased basal plasma cortisol and increased resting blood pressure at 2.5 years old compared to CC. These males had increased blood pressure responsiveness to RAS stimulation using frusemide at 1.5 years old and altered HR responsiveness to Ang II at 2.5 years old CU males, but not females, had increased basal plasma cortisol and ACTH at 1.5 years and 2.5 years of age compared to CC. This could therefore contribute to the increased blood pressure responses to frusemide at both 1.5 and 2.5 years old, and to Ang I and Ang II at 2.5 years old in these males. These effects were not seen if early gestation nutrient restriction was also received (UU).
These findings are sex specific and may have important implications for the human population and inform on future interventions aimed at reducing chronic diseases (e.g. CHD).
University of Southampton
Cleal, Jane Katherine
c30290a6-b6b8-4df3-a56e-e49cf93fc7c1
2005
Cleal, Jane Katherine
c30290a6-b6b8-4df3-a56e-e49cf93fc7c1
Cleal, Jane Katherine
(2005)
The renin-angiotensin system and its role in ovine cardiovascular control and growth following early gestation and early postnatal nutrient restriction.
University of Southampton, Doctoral Thesis.
Record type:
Thesis
(Doctoral)
Abstract
The aim of this thesis was to investigate, in terms of RAS-mediated cardiovascular control, the concept that the prenatal predictive adaptive responses to undernutrition may establish a phenotype which determines how the individual responds to the postnatal environment.
Welsh Mountain ewes received 100 % (C) or 50 % (U) of total nutrient requirements from 1-31 days gestational age (dGA), and 100 % thereafter. At 70 dGA a subset of fetuses were removed for subsequent molecular and histological analysis. Offspring were fed ad libitum (CC & UC) or at a level that reduced body weight to 85 % of individual target weight from 12 to 25 weeks postnatal age and ad libitum thereafter (CU & UU).
UC males, but not females, had increased early postnatal growth, increased basal plasma cortisol and increased resting blood pressure at 2.5 years old compared to CC. These males had increased blood pressure responsiveness to RAS stimulation using frusemide at 1.5 years old and altered HR responsiveness to Ang II at 2.5 years old CU males, but not females, had increased basal plasma cortisol and ACTH at 1.5 years and 2.5 years of age compared to CC. This could therefore contribute to the increased blood pressure responses to frusemide at both 1.5 and 2.5 years old, and to Ang I and Ang II at 2.5 years old in these males. These effects were not seen if early gestation nutrient restriction was also received (UU).
These findings are sex specific and may have important implications for the human population and inform on future interventions aimed at reducing chronic diseases (e.g. CHD).
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Published date: 2005
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Local EPrints ID: 465906
URI: http://eprints.soton.ac.uk/id/eprint/465906
PURE UUID: 38c9dc38-c6f9-4517-8c15-490f21672064
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Date deposited: 05 Jul 2022 03:31
Last modified: 23 Jul 2022 01:14
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Author:
Jane Katherine Cleal
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