Food hypersensitivity amongst children on the Isle of Wight : an in depth dietary investigation
Food hypersensitivity amongst children on the Isle of Wight : an in depth dietary investigation
Introduction: It is unclear at present which type of food challenge (open vs. double blind) is best suited for the diagnosis of food hypersensitivity (FHS) in children.
This research aimed to assess 1) what is the best approach for the diagnosis of FHS; 2) how maternal dietary and infant feeding and weaning practices influence the development of FHS; 3) the role of a personal or family history of atopy in dietary practices.
Methods: A birth cohort of children born during 2001 - 2002 was recruited at the ante-natal clinic and followed prospectively for two years. In addition, three sets of school cohorts were approached to participate in the study. To address the first aim, all cohorts were utilised and the use of open food challenges (OFC) and double blind placebo controlled food challenges (DBPCFC) were assessed in the diagnosis of FHS. To address the second aim the birth cohort was used. A food frequency questionnaire (FFQ) was developed and validated to obtain the information on the maternal diet. Standardised questionnaires were developed and used prospectively to assess feeding and weaning practices and their influence on the infant’s FHS. To address the third aim the family history of atopy was obtained during recruitment of the birth cohort.
Results: We found that the positive predictive value of the one-day OFC challenges was higher than the one-week OFC. The data therefore suggest that OFC may be suitable for diagnosing immediate (objective) symptoms, whereas a DBPCFC may be needed for the diagnosis of delayed (subjective) symptoms.
Fruit and vegetable intake during pregnancy, food avoidance during lactation and weaning age of the infant affected the development of FHS.
A family history of atopy positively affected exclusive breast feeding at three months and delayed introduction of peanuts into the infant’s diet by six months.
University of Southampton
Venter, Carina
a9b7dd5e-b0cb-4068-be82-e15b587cc20b
2006
Venter, Carina
a9b7dd5e-b0cb-4068-be82-e15b587cc20b
Venter, Carina
(2006)
Food hypersensitivity amongst children on the Isle of Wight : an in depth dietary investigation.
University of Southampton, Doctoral Thesis.
Record type:
Thesis
(Doctoral)
Abstract
Introduction: It is unclear at present which type of food challenge (open vs. double blind) is best suited for the diagnosis of food hypersensitivity (FHS) in children.
This research aimed to assess 1) what is the best approach for the diagnosis of FHS; 2) how maternal dietary and infant feeding and weaning practices influence the development of FHS; 3) the role of a personal or family history of atopy in dietary practices.
Methods: A birth cohort of children born during 2001 - 2002 was recruited at the ante-natal clinic and followed prospectively for two years. In addition, three sets of school cohorts were approached to participate in the study. To address the first aim, all cohorts were utilised and the use of open food challenges (OFC) and double blind placebo controlled food challenges (DBPCFC) were assessed in the diagnosis of FHS. To address the second aim the birth cohort was used. A food frequency questionnaire (FFQ) was developed and validated to obtain the information on the maternal diet. Standardised questionnaires were developed and used prospectively to assess feeding and weaning practices and their influence on the infant’s FHS. To address the third aim the family history of atopy was obtained during recruitment of the birth cohort.
Results: We found that the positive predictive value of the one-day OFC challenges was higher than the one-week OFC. The data therefore suggest that OFC may be suitable for diagnosing immediate (objective) symptoms, whereas a DBPCFC may be needed for the diagnosis of delayed (subjective) symptoms.
Fruit and vegetable intake during pregnancy, food avoidance during lactation and weaning age of the infant affected the development of FHS.
A family history of atopy positively affected exclusive breast feeding at three months and delayed introduction of peanuts into the infant’s diet by six months.
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Published date: 2006
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Local EPrints ID: 465907
URI: http://eprints.soton.ac.uk/id/eprint/465907
PURE UUID: d48de2cf-a060-4186-9f3c-1d6d7d5ae6cb
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Date deposited: 05 Jul 2022 03:31
Last modified: 16 Mar 2024 20:25
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Author:
Carina Venter
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