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Optimising coherence estimation to assess the functional correlation of tremor-related activity between the subthalamic nucleus and forearm muscles

Optimising coherence estimation to assess the functional correlation of tremor-related activity between the subthalamic nucleus and forearm muscles
Optimising coherence estimation to assess the functional correlation of tremor-related activity between the subthalamic nucleus and forearm muscles
Application of coherence estimation needs not only to correctly estimate coherence values but also to efficiently test the statistical significance of the estimates. In the present report, we have explained the approach of optimising a coherence estimator by restricting its normalised bias error and random error. In addition to the commonly used independence threshold, two more tests based on the probability of detection and the exact confidence interval have been proposed for detecting the significance of the coherence estimates. All three methods have been used to evaluate the significant functional correlation between oscillatory field potentials (FPs) in the subthalamic nucleus (STN) and the surface electromyogram (EMG) of the forearm muscles during tremor in Parkinson’s disease.
coherence estimation, statistics, field potential, subthalamic nucleus, electromyogram, parkinson’s disease, tremor, stn, FPs, field potentials, dbs, deep brain stimulation, EMGs, electromyograms, msc, magnitude squared coherence
0165-0270
197-205
Wang, Shou-Yan
f08e1454-91d3-4403-b4b6-d1d9eba6961b
Liu, Xuguang
82f0b077-5b67-495b-92be-5cf1ed8d7bb1
Yianni, John
940fddfe-1c78-4845-9d1a-3d667d27be72
Miall, R. Christopher
57b0bfe2-b816-4bc7-ba8b-d826f70af1d9
Aziz, Tipu Z.
84768d79-fc87-4c3e-8955-d2e72ca5e6a0
Stein, John F.
341274f8-3eee-4614-958c-635e0b498d78
Wang, Shou-Yan
f08e1454-91d3-4403-b4b6-d1d9eba6961b
Liu, Xuguang
82f0b077-5b67-495b-92be-5cf1ed8d7bb1
Yianni, John
940fddfe-1c78-4845-9d1a-3d667d27be72
Miall, R. Christopher
57b0bfe2-b816-4bc7-ba8b-d826f70af1d9
Aziz, Tipu Z.
84768d79-fc87-4c3e-8955-d2e72ca5e6a0
Stein, John F.
341274f8-3eee-4614-958c-635e0b498d78

Wang, Shou-Yan, Liu, Xuguang, Yianni, John, Miall, R. Christopher, Aziz, Tipu Z. and Stein, John F. (2004) Optimising coherence estimation to assess the functional correlation of tremor-related activity between the subthalamic nucleus and forearm muscles. Journal of Neuroscience Methods, 136 (2), 197-205. (doi:10.1016/j.jneumeth.2004.01.008).

Record type: Article

Abstract

Application of coherence estimation needs not only to correctly estimate coherence values but also to efficiently test the statistical significance of the estimates. In the present report, we have explained the approach of optimising a coherence estimator by restricting its normalised bias error and random error. In addition to the commonly used independence threshold, two more tests based on the probability of detection and the exact confidence interval have been proposed for detecting the significance of the coherence estimates. All three methods have been used to evaluate the significant functional correlation between oscillatory field potentials (FPs) in the subthalamic nucleus (STN) and the surface electromyogram (EMG) of the forearm muscles during tremor in Parkinson’s disease.

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More information

Published date: 30 July 2004
Keywords: coherence estimation, statistics, field potential, subthalamic nucleus, electromyogram, parkinson’s disease, tremor, stn, FPs, field potentials, dbs, deep brain stimulation, EMGs, electromyograms, msc, magnitude squared coherence
Organisations: Human Sciences Group

Identifiers

Local EPrints ID: 46598
URI: https://eprints.soton.ac.uk/id/eprint/46598
ISSN: 0165-0270
PURE UUID: c22d725d-f085-44b4-9da5-9d3f68e345e3

Catalogue record

Date deposited: 12 Jul 2007
Last modified: 13 Mar 2019 21:02

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Contributors

Author: Shou-Yan Wang
Author: Xuguang Liu
Author: John Yianni
Author: R. Christopher Miall
Author: Tipu Z. Aziz
Author: John F. Stein

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