The University of Southampton
University of Southampton Institutional Repository

Involvement of human basal ganglia in off-line feed-back control of voluntary movement

Involvement of human basal ganglia in off-line feed-back control of voluntary movement
Involvement of human basal ganglia in off-line feed-back control of voluntary movement
Practice makes perfect, but the neural substrates of trial-to-trial learning in motor tasks remain unclear. There is some evidence that the basal ganglia process feedback-related information to modify learning in essentially cognitive tasks 1, 2, 3 and 4, but the evidence that these key motor structures are involved in offline feedback-related improvement of performance in motor tasks is paradoxically limited. Lesion studies in adult zebra finches suggest that the avian basal ganglia are involved in the transmission or production of an error signal during song 5, 6 and 7. However, patients with Huntington's disease, in which there is prominent basal ganglia dysfunction, are not impaired in error-dependent modulation of future trial performance [8]. By directly recording from the subthalamic nucleus in patients with Parkinson's disease, we demonstrate that this nucleus processes error in trial performance at short latency. Local evoked activity is greatest in response to smallest errors and influences the programming of subsequent movements. Accordingly, motor parameters are least likely to change after the greatest evoked responses so that accurately performed trials tend to precede other accurate trials. This relationship is disrupted by electrical stimulation of the nucleus at high frequency. Thus, the human subthalamic nucleus is involved in feedback-based learning.
sysneuro
0960-9822
2129-2134
Brown, Peter
e21132aa-29de-4c0e-846a-f090ddda0dbc
Chen, Chiung Chu
7144ce0e-e627-4351-a385-b24241eca225
Wang, Shouyan
fa12f1bf-cac9-4118-abdd-9d52f235b05c
Kühn, Andrea A.
475dc97e-ceda-4425-831a-e23e8a89ef52
Doyle, Louise
05fb5917-1367-4c76-9206-eb4aecd600f2
Yarrow, Kielan
f00fd7c7-686a-4295-b013-decadc332ea0
Stein, John
90a56aca-508d-442a-a656-ba4c313eaca8
Nuttin, Bart
37b4417b-3f48-4af8-8556-0d562fffb808
Aziz, Tipu
27210844-403d-41e7-bfc1-b87c4b8a4308
Brown, Peter
e21132aa-29de-4c0e-846a-f090ddda0dbc
Chen, Chiung Chu
7144ce0e-e627-4351-a385-b24241eca225
Wang, Shouyan
fa12f1bf-cac9-4118-abdd-9d52f235b05c
Kühn, Andrea A.
475dc97e-ceda-4425-831a-e23e8a89ef52
Doyle, Louise
05fb5917-1367-4c76-9206-eb4aecd600f2
Yarrow, Kielan
f00fd7c7-686a-4295-b013-decadc332ea0
Stein, John
90a56aca-508d-442a-a656-ba4c313eaca8
Nuttin, Bart
37b4417b-3f48-4af8-8556-0d562fffb808
Aziz, Tipu
27210844-403d-41e7-bfc1-b87c4b8a4308

Brown, Peter, Chen, Chiung Chu, Wang, Shouyan, Kühn, Andrea A., Doyle, Louise, Yarrow, Kielan, Stein, John, Nuttin, Bart and Aziz, Tipu (2006) Involvement of human basal ganglia in off-line feed-back control of voluntary movement. Current Biology, 16 (21), 2129-2134. (doi:10.1016/j.cub.2006.08.088).

Record type: Article

Abstract

Practice makes perfect, but the neural substrates of trial-to-trial learning in motor tasks remain unclear. There is some evidence that the basal ganglia process feedback-related information to modify learning in essentially cognitive tasks 1, 2, 3 and 4, but the evidence that these key motor structures are involved in offline feedback-related improvement of performance in motor tasks is paradoxically limited. Lesion studies in adult zebra finches suggest that the avian basal ganglia are involved in the transmission or production of an error signal during song 5, 6 and 7. However, patients with Huntington's disease, in which there is prominent basal ganglia dysfunction, are not impaired in error-dependent modulation of future trial performance [8]. By directly recording from the subthalamic nucleus in patients with Parkinson's disease, we demonstrate that this nucleus processes error in trial performance at short latency. Local evoked activity is greatest in response to smallest errors and influences the programming of subsequent movements. Accordingly, motor parameters are least likely to change after the greatest evoked responses so that accurately performed trials tend to precede other accurate trials. This relationship is disrupted by electrical stimulation of the nucleus at high frequency. Thus, the human subthalamic nucleus is involved in feedback-based learning.

Full text not available from this repository.

More information

Published date: 7 November 2006
Keywords: sysneuro
Organisations: Human Sciences Group

Identifiers

Local EPrints ID: 46600
URI: http://eprints.soton.ac.uk/id/eprint/46600
ISSN: 0960-9822
PURE UUID: ffce530a-0f59-4e46-9396-54fa0442e08d

Catalogue record

Date deposited: 12 Jul 2007
Last modified: 13 Mar 2019 21:02

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×