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Stimulating the human midbrain to reveal the link between pain and blood pressure

Green, Alexander L., Wang, Shouyan, Owen, Sarah, Xie, Kangning, Bittar, Richard G., Stein, John F., Paterson, David J. and Aziz, Tipu Z. (2006) Stimulating the human midbrain to reveal the link between pain and blood pressure Pain, 124, (3), pp. 349-359. (doi:10.1016/j.pain.2006.05.005).

Record type: Article


The periaqueductal grey area (PAG) in the midbrain is an important area for both cardiovascular control and modulation of pain. However, the precise relationship between pain and blood pressure is unknown. We prospectively studied 16 patients undergoing deep brain stimulation of the rostral PAG for chronic pain. Pre-operatively, post-operatively, and at 1 year, pain scores were assessed using both visual analogue scores and the McGill Pain Questionnaire. Patients were tested post-operatively to determine whether electrical stimulation of the PAG would modulate blood pressure. We found that the degree of analgesia induced by deep brain stimulation of the rostral PAG in man is related to the magnitude of reduction in arterial blood pressure. We found that this relationship is linear and is related to reduced activity of the sympathetic nervous system. Thus stimulation of the PAG may partly control pain by reducing sympathetic activity as predicted by William James over a century ago.

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Published date: October 2006
Keywords: pain, deep brain stimulation, blood pressure, mcgill pain questionnaire, visual analogue score, periaqueductal grey, pag
Organisations: Human Sciences Group


Local EPrints ID: 46602
ISSN: 0304-3959
PURE UUID: f2a6a396-578e-4af2-b95b-7a9e8bc90fca

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Date deposited: 12 Jul 2007
Last modified: 17 Jul 2017 15:06

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Author: Alexander L. Green
Author: Shouyan Wang
Author: Sarah Owen
Author: Kangning Xie
Author: Richard G. Bittar
Author: John F. Stein
Author: David J. Paterson
Author: Tipu Z. Aziz

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