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Different mechanisms may generate sustained hypertonic and rhythmic bursting muscle activity in idiopathic dystonia

Different mechanisms may generate sustained hypertonic and rhythmic bursting muscle activity in idiopathic dystonia
Different mechanisms may generate sustained hypertonic and rhythmic bursting muscle activity in idiopathic dystonia
Despite that deep brain stimulation (DBS) of the globus pallidus internus (GPi) is emerging as the favored intervention for patients with medically intractable dystonia, the pathophysiological mechanisms of dystonia are largely unclear. In eight patients with primary dystonia who were treated with bilateral chronic pallidal stimulation, we correlated symptom-related electromyogram (EMG) activity of the most affected muscles with the local field potentials (LFPs) recorded from the globus pallidus electrodes. In 5 dystonic patients with mobile involuntary movements, rhythmic EMG bursts in the contralateral muscles were coherent with the oscillations in the pallidal LFPs at the burst frequency. In contrast, no significant coherence was seen between EMG and LFPs either for the sustained activity separated out from the compound EMGs in those 5 cases, or in the EMGs in 3 other cases without mobile involuntary movements and rhythmic EMG bursts. In comparison with the resting condition, in both active and passive movements, significant modulation in the GPi LFPs was seen in the range of 8–16 Hz. The finding of significant coherence between GPi oscillations and rhythmic EMG bursts but not sustained tonic EMG activity suggests that the synchronized pallidal activity may be directly related to the rhythmic involuntary movements. In contrast, the sustained hypertonic muscle activity may be represented by less synchronized activity in the pallidum. Thus, the pallidum may play different roles in generating different components of the dystonic symptom complex.
0014-4886
204-213
Liu, Xuguang
82f0b077-5b67-495b-92be-5cf1ed8d7bb1
Yianni, John
940fddfe-1c78-4845-9d1a-3d667d27be72
Wang, Shouyan
fa12f1bf-cac9-4118-abdd-9d52f235b05c
Bain, Peter G.
a9691e26-7129-4eae-80b8-29e76b0ba31b
Stein, John F.
341274f8-3eee-4614-958c-635e0b498d78
Aziz, Tipu Z.
84768d79-fc87-4c3e-8955-d2e72ca5e6a0
Liu, Xuguang
82f0b077-5b67-495b-92be-5cf1ed8d7bb1
Yianni, John
940fddfe-1c78-4845-9d1a-3d667d27be72
Wang, Shouyan
fa12f1bf-cac9-4118-abdd-9d52f235b05c
Bain, Peter G.
a9691e26-7129-4eae-80b8-29e76b0ba31b
Stein, John F.
341274f8-3eee-4614-958c-635e0b498d78
Aziz, Tipu Z.
84768d79-fc87-4c3e-8955-d2e72ca5e6a0

Liu, Xuguang, Yianni, John, Wang, Shouyan, Bain, Peter G., Stein, John F. and Aziz, Tipu Z. (2006) Different mechanisms may generate sustained hypertonic and rhythmic bursting muscle activity in idiopathic dystonia. Experimental Neurology, 198 (1), 204-213. (doi:10.1016/j.expneurol.2005.11.018).

Record type: Article

Abstract

Despite that deep brain stimulation (DBS) of the globus pallidus internus (GPi) is emerging as the favored intervention for patients with medically intractable dystonia, the pathophysiological mechanisms of dystonia are largely unclear. In eight patients with primary dystonia who were treated with bilateral chronic pallidal stimulation, we correlated symptom-related electromyogram (EMG) activity of the most affected muscles with the local field potentials (LFPs) recorded from the globus pallidus electrodes. In 5 dystonic patients with mobile involuntary movements, rhythmic EMG bursts in the contralateral muscles were coherent with the oscillations in the pallidal LFPs at the burst frequency. In contrast, no significant coherence was seen between EMG and LFPs either for the sustained activity separated out from the compound EMGs in those 5 cases, or in the EMGs in 3 other cases without mobile involuntary movements and rhythmic EMG bursts. In comparison with the resting condition, in both active and passive movements, significant modulation in the GPi LFPs was seen in the range of 8–16 Hz. The finding of significant coherence between GPi oscillations and rhythmic EMG bursts but not sustained tonic EMG activity suggests that the synchronized pallidal activity may be directly related to the rhythmic involuntary movements. In contrast, the sustained hypertonic muscle activity may be represented by less synchronized activity in the pallidum. Thus, the pallidum may play different roles in generating different components of the dystonic symptom complex.

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Published date: March 2006
Organisations: Human Sciences Group

Identifiers

Local EPrints ID: 46603
URI: http://eprints.soton.ac.uk/id/eprint/46603
ISSN: 0014-4886
PURE UUID: 88797326-a768-45c5-85c3-ea39657dda85

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Date deposited: 12 Jul 2007
Last modified: 13 Mar 2019 21:02

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