Plasma fatty acid composition of patients with colectomy and the influences on their metabolism
Plasma fatty acid composition of patients with colectomy and the influences on their metabolism
The fatty acid compositions of plasma phosphatidylcholine (PC), triacylglycerol (TAG), non-esterified fatty acids (NEFA) and cholesteryl ester (CE) were determined in a healthy reference group and patients with established colectomy (CO), including a small subset of patients with additional small bowel resection (SB). Acute phase proteins were measured in the colectomy patients and these were not suggestive of any significant ongoing inflammation. Dietary intakes were also assessed in the reference and patient groups and were not indicative of any significant differences.
Colectomy patients exhibited significant alterations to their plasma fatty acid compositions. Data were presented as absolute concentration and relative (%) proportions. This highlighted the need to provide data in dual format as differences in concentrations often did not concur when expressed in relative terms. Significantly higher concentrations of PC and TAG fatty acids were seen and were more apparent in the SB subset. Several differences were also noted in CE and NEFA fatty acids in the colectomy group which were also more marked in SB patients. Concentrations and proportions of α-linolenic (ALNA) and docosahexaenoic acids (DHA) were consistently lower in all fractions and again to a greater magnitude in the SB subset.
The results suggested a potential involvement of lipid maldigestion and/or malabsorption processes in the pathogenesis of disturbed lipid profiles, particularly to n-3 PUFA. It is suggested that hepatic lipid export may be stimulated, potentially by low n-3 PUFA availability, resulting in raised plasma lipid concentrations and potential health risks associated with this. However, more research is needed to confirm these findings.
University of Southampton
May, Angela Nicola Jayne
e4aebd72-a926-4c96-8005-602ab06a25ec
2007
May, Angela Nicola Jayne
e4aebd72-a926-4c96-8005-602ab06a25ec
May, Angela Nicola Jayne
(2007)
Plasma fatty acid composition of patients with colectomy and the influences on their metabolism.
University of Southampton, Doctoral Thesis.
Record type:
Thesis
(Doctoral)
Abstract
The fatty acid compositions of plasma phosphatidylcholine (PC), triacylglycerol (TAG), non-esterified fatty acids (NEFA) and cholesteryl ester (CE) were determined in a healthy reference group and patients with established colectomy (CO), including a small subset of patients with additional small bowel resection (SB). Acute phase proteins were measured in the colectomy patients and these were not suggestive of any significant ongoing inflammation. Dietary intakes were also assessed in the reference and patient groups and were not indicative of any significant differences.
Colectomy patients exhibited significant alterations to their plasma fatty acid compositions. Data were presented as absolute concentration and relative (%) proportions. This highlighted the need to provide data in dual format as differences in concentrations often did not concur when expressed in relative terms. Significantly higher concentrations of PC and TAG fatty acids were seen and were more apparent in the SB subset. Several differences were also noted in CE and NEFA fatty acids in the colectomy group which were also more marked in SB patients. Concentrations and proportions of α-linolenic (ALNA) and docosahexaenoic acids (DHA) were consistently lower in all fractions and again to a greater magnitude in the SB subset.
The results suggested a potential involvement of lipid maldigestion and/or malabsorption processes in the pathogenesis of disturbed lipid profiles, particularly to n-3 PUFA. It is suggested that hepatic lipid export may be stimulated, potentially by low n-3 PUFA availability, resulting in raised plasma lipid concentrations and potential health risks associated with this. However, more research is needed to confirm these findings.
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Published date: 2007
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Local EPrints ID: 466278
URI: http://eprints.soton.ac.uk/id/eprint/466278
PURE UUID: fe9b0fa3-0d5c-497a-9d41-694e9427bdae
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Date deposited: 05 Jul 2022 05:01
Last modified: 16 Mar 2024 20:36
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Author:
Angela Nicola Jayne May
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