The impact of diet in pregnancy on fetal renal and cardiovascular development
The impact of diet in pregnancy on fetal renal and cardiovascular development
In the first study ewes received either 100% (C) or 50% (R) of total nutrient requirements for the first 31 days of gestation (dGA), and 100% requirements thereafter. In the second study ewes received either 100% (C) of total nutrient requirements throughout gestation, 40% (E) from 1-31 dGA or 50% (L) from 104 dGA onwards, at all other times ewes were fed 100% requirements. In late gestation, fetuses were surgically instrumented and basal CV and renal parameters, and responses to a number of stimuli were measured.
The first study found that a 50% maternal nutrient restriction did not alter fetal body or organ weights, kidney biometry, basal CV function or baroreflex during late gestation. 50% maternal nutrient restriction had no effect on fetal renin angiotensin system (RAS) in terms of CV or renal response to frusemide. However, the responsiveness to Angiotensin II (Ang II) was blunted in the maternal restricted fetuses. The second study found that neither a more severe peri-implantation nor a late gestation maternal nutrient restriction altered any of the fetal parameters measured in the first study. Maternal nutrient restriction did not alter fetal nephron number in late gestation. There was no difference between the groups in the overall CV response to hypoxia.
These findings suggest that poor in utero nutrition does not alter renal development and function, basal CV control, baroreflex or chemoreflex in fetal life. Peri-implantation restriction blunted the fetal mean arterial pressure response to Ang II, dependent on intensity of challenge, which may indicate altered Ang II receptors populations in the peripheral vasculature. In conclusion reduced maternal nutrition during peri-implantation and late gestation, periods previously implicated as critical periods of development, appear to have no effect on fetal renal development.
University of Southampton
Braddick, Lucinda Mary
8a5b93ef-8bd1-4fc4-a8f3-2110b8e79393
2007
Braddick, Lucinda Mary
8a5b93ef-8bd1-4fc4-a8f3-2110b8e79393
Braddick, Lucinda Mary
(2007)
The impact of diet in pregnancy on fetal renal and cardiovascular development.
University of Southampton, Doctoral Thesis.
Record type:
Thesis
(Doctoral)
Abstract
In the first study ewes received either 100% (C) or 50% (R) of total nutrient requirements for the first 31 days of gestation (dGA), and 100% requirements thereafter. In the second study ewes received either 100% (C) of total nutrient requirements throughout gestation, 40% (E) from 1-31 dGA or 50% (L) from 104 dGA onwards, at all other times ewes were fed 100% requirements. In late gestation, fetuses were surgically instrumented and basal CV and renal parameters, and responses to a number of stimuli were measured.
The first study found that a 50% maternal nutrient restriction did not alter fetal body or organ weights, kidney biometry, basal CV function or baroreflex during late gestation. 50% maternal nutrient restriction had no effect on fetal renin angiotensin system (RAS) in terms of CV or renal response to frusemide. However, the responsiveness to Angiotensin II (Ang II) was blunted in the maternal restricted fetuses. The second study found that neither a more severe peri-implantation nor a late gestation maternal nutrient restriction altered any of the fetal parameters measured in the first study. Maternal nutrient restriction did not alter fetal nephron number in late gestation. There was no difference between the groups in the overall CV response to hypoxia.
These findings suggest that poor in utero nutrition does not alter renal development and function, basal CV control, baroreflex or chemoreflex in fetal life. Peri-implantation restriction blunted the fetal mean arterial pressure response to Ang II, dependent on intensity of challenge, which may indicate altered Ang II receptors populations in the peripheral vasculature. In conclusion reduced maternal nutrition during peri-implantation and late gestation, periods previously implicated as critical periods of development, appear to have no effect on fetal renal development.
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Published date: 2007
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Local EPrints ID: 466353
URI: http://eprints.soton.ac.uk/id/eprint/466353
PURE UUID: 03f35309-6d87-4b40-9718-02d7d7cb5731
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Date deposited: 05 Jul 2022 05:12
Last modified: 16 Mar 2024 20:39
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Author:
Lucinda Mary Braddick
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