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Apicomplexan-like parasites are polyphyletic and widely but selectively dependent on cryptic plastid organelles

Apicomplexan-like parasites are polyphyletic and widely but selectively dependent on cryptic plastid organelles
Apicomplexan-like parasites are polyphyletic and widely but selectively dependent on cryptic plastid organelles
The phylum Apicomplexa comprises human pathogens such as Plasmodium but is also an under-explored hotspot of evolutionary diversity central to understanding the origins of parasitism and non-photosynthetic plastids. We generated single-cell transcriptomes for all major apicomplexan groups lacking large-scale sequence data. Phylogenetic analysis reveals that apicomplexan-like parasites are polyphyletic and their similar morphologies emerged convergently at least three times. Gregarines and eugregarines are monophyletic, against most expectations, and rhytidocystids and Eleutheroschizon are sister lineages to medically important taxa. Although previously unrecognized, plastids in deep-branching apicomplexans are common, and they contain some of the most divergent and AT-rich genomes ever found. In eugregarines, however, plastids are either abnormally reduced or absent, thus increasing known plastid losses in eukaryotes from two to four. Environmental sequences of ten novel plastid lineages and structural innovations in plastid proteins confirm that plastids in apicomplexans and their relatives are widespread and share a common, photosynthetic origin.
2050-084X
Janouskovec, Jan
fbaa4a5d-872e-465b-b2c3-bb35df455cc6
Paskerova, Gita G.
60109f96-ba02-4b3d-baa0-200246bc9201
Miroliubova, Tatiana S.
6223e19a-ece4-4821-ad41-4c07f5962650
Mikhailov, Kirill
98f78548-d981-496a-b066-025565f69363
Birley, Thomas
9d2274f5-78f3-4638-ab31-2f314f8bcfbc
Aleoshin, Vladimir V.
96f45de0-b518-46fc-882f-c3f15ddb629a
Simdyanov, Timur G.
6ecfaba3-1c94-4602-a933-1805ea4b5e9d
Janouskovec, Jan
fbaa4a5d-872e-465b-b2c3-bb35df455cc6
Paskerova, Gita G.
60109f96-ba02-4b3d-baa0-200246bc9201
Miroliubova, Tatiana S.
6223e19a-ece4-4821-ad41-4c07f5962650
Mikhailov, Kirill
98f78548-d981-496a-b066-025565f69363
Birley, Thomas
9d2274f5-78f3-4638-ab31-2f314f8bcfbc
Aleoshin, Vladimir V.
96f45de0-b518-46fc-882f-c3f15ddb629a
Simdyanov, Timur G.
6ecfaba3-1c94-4602-a933-1805ea4b5e9d

Janouskovec, Jan, Paskerova, Gita G., Miroliubova, Tatiana S., Mikhailov, Kirill, Birley, Thomas, Aleoshin, Vladimir V. and Simdyanov, Timur G. (2019) Apicomplexan-like parasites are polyphyletic and widely but selectively dependent on cryptic plastid organelles. eLife, 8. (doi:10.7554/ELIFE.49662).

Record type: Article

Abstract

The phylum Apicomplexa comprises human pathogens such as Plasmodium but is also an under-explored hotspot of evolutionary diversity central to understanding the origins of parasitism and non-photosynthetic plastids. We generated single-cell transcriptomes for all major apicomplexan groups lacking large-scale sequence data. Phylogenetic analysis reveals that apicomplexan-like parasites are polyphyletic and their similar morphologies emerged convergently at least three times. Gregarines and eugregarines are monophyletic, against most expectations, and rhytidocystids and Eleutheroschizon are sister lineages to medically important taxa. Although previously unrecognized, plastids in deep-branching apicomplexans are common, and they contain some of the most divergent and AT-rich genomes ever found. In eugregarines, however, plastids are either abnormally reduced or absent, thus increasing known plastid losses in eukaryotes from two to four. Environmental sequences of ten novel plastid lineages and structural innovations in plastid proteins confirm that plastids in apicomplexans and their relatives are widespread and share a common, photosynthetic origin.

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More information

Accepted/In Press date: 14 August 2019
Published date: 16 August 2019
Additional Information: Copyright Janouskovec et al

Identifiers

Local EPrints ID: 466398
URI: http://eprints.soton.ac.uk/id/eprint/466398
ISSN: 2050-084X
PURE UUID: ed61c872-0cc2-4762-b523-275db1376d90
ORCID for Jan Janouskovec: ORCID iD orcid.org/0000-0001-6547-749X

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Date deposited: 05 Jul 2022 05:14
Last modified: 13 Aug 2022 02:09

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Contributors

Author: Jan Janouskovec ORCID iD
Author: Gita G. Paskerova
Author: Tatiana S. Miroliubova
Author: Kirill Mikhailov
Author: Thomas Birley
Author: Vladimir V. Aleoshin
Author: Timur G. Simdyanov

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