Development of selective non-metal based organocatalysts for asymmetric synthesis
Development of selective non-metal based organocatalysts for asymmetric synthesis
This thesis is concerned with the design, synthesis and use of novel bifunctional organocatalysts for the asymmetric Michael addition of ketones and 1, 3 – dicarbonyl compounds to trans - β - nitrostyrene.
Chapter 1 describes the concept of organocatalysis, including history and mode of action. A detailed review is provided on the organocatalytic Michael addition of carbon nucleophiles to nitroolefins. The bifunctional organocatalyst design and programme of work is also discussed.
Chapter 2 details initial investigations conducted on the organocatalytic Michael addition of cyclohexanone to trans - β - nitrostyrene using monofunctional amine catalysts and hydrogen bond donor catalysts.
Chapters 3, 4 and 5 depict the synthesis and testing of a range of novel bifunctional organocatalysts for the Michael addition of cyclohexanone to trans - β - nitrostyrene.
Chapter 6 compares the different bifunctional organocatalysts and explores the scope of the catalysts and the Michael addition reaction.
University of Southampton
Carley, Allison Patricia
40979405-2dfb-4821-b92f-2db29f60cf13
2007
Carley, Allison Patricia
40979405-2dfb-4821-b92f-2db29f60cf13
Carley, Allison Patricia
(2007)
Development of selective non-metal based organocatalysts for asymmetric synthesis.
University of Southampton, Doctoral Thesis.
Record type:
Thesis
(Doctoral)
Abstract
This thesis is concerned with the design, synthesis and use of novel bifunctional organocatalysts for the asymmetric Michael addition of ketones and 1, 3 – dicarbonyl compounds to trans - β - nitrostyrene.
Chapter 1 describes the concept of organocatalysis, including history and mode of action. A detailed review is provided on the organocatalytic Michael addition of carbon nucleophiles to nitroolefins. The bifunctional organocatalyst design and programme of work is also discussed.
Chapter 2 details initial investigations conducted on the organocatalytic Michael addition of cyclohexanone to trans - β - nitrostyrene using monofunctional amine catalysts and hydrogen bond donor catalysts.
Chapters 3, 4 and 5 depict the synthesis and testing of a range of novel bifunctional organocatalysts for the Michael addition of cyclohexanone to trans - β - nitrostyrene.
Chapter 6 compares the different bifunctional organocatalysts and explores the scope of the catalysts and the Michael addition reaction.
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Published date: 2007
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Local EPrints ID: 466439
URI: http://eprints.soton.ac.uk/id/eprint/466439
PURE UUID: 17cd16a5-ce90-426f-9fdc-791d21906bf3
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Date deposited: 05 Jul 2022 05:16
Last modified: 16 Mar 2024 20:42
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Author:
Allison Patricia Carley
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