Digestion, absorbtion and metabolic disposal of dietary lipid in cystic fibrosis patients and control subjects
Digestion, absorbtion and metabolic disposal of dietary lipid in cystic fibrosis patients and control subjects
The aims of this thesis were 1) to develop and evaluate a method which may be used to differentiate between maldigestion and malabsorption of dietary lipid, 2) to determine amount and type of stool lipid losses and 3) to investigate metabolic disposal of absorbed lipid in patients compared to controls.
A combination of novel stable isotope technology and traditional techniques was used to study gastrointestinal handling and metabolic disposal of dietary lipid. Cystic fibrosis patients with gastrostomies and controls subjects received [1, 1, 1-13C]tripalmitin (10 mg/kg body weight) as an emulsion drink with a standardised breakfast. Maldigestion and malabsorption of dietary lipid were determined as label losses in stools and stool lipid fractions whilst metabolic disposal was determined as label excretion on breath over the 10 hour postprandial period.
The results highlight differences between patients in the extent to which they may digest and absorb dietary lipid and the need to target the management according to causes of stool lipid losses. Whilst malabsorption was indicated in most patients, were patents appeared to have evidence of maldigestion. Thus, adjusting enzyme therapy has no advantages in patients who malabsorb dietary lipid and management should be focused on resolving malabsorption. Metabolism of absorbed lipid was altered in these patients and was due to a reduced oxidation of dietary lipid over the postprandial period. This altered metabolism may impact upon subsequent growth and body composition of patients and has implications for the use of breath tests in defining the capacity of gastrointestinal tract to digest and absorb dietary lipid. A model for the assessment and management of patients with weight loss or distributed growth was proposed.
University of Southampton
Laiho, Kirsi Marjut
568f695f-e22b-485a-b902-a84e2c7c81c5
2000
Laiho, Kirsi Marjut
568f695f-e22b-485a-b902-a84e2c7c81c5
Laiho, Kirsi Marjut
(2000)
Digestion, absorbtion and metabolic disposal of dietary lipid in cystic fibrosis patients and control subjects.
University of Southampton, Doctoral Thesis.
Record type:
Thesis
(Doctoral)
Abstract
The aims of this thesis were 1) to develop and evaluate a method which may be used to differentiate between maldigestion and malabsorption of dietary lipid, 2) to determine amount and type of stool lipid losses and 3) to investigate metabolic disposal of absorbed lipid in patients compared to controls.
A combination of novel stable isotope technology and traditional techniques was used to study gastrointestinal handling and metabolic disposal of dietary lipid. Cystic fibrosis patients with gastrostomies and controls subjects received [1, 1, 1-13C]tripalmitin (10 mg/kg body weight) as an emulsion drink with a standardised breakfast. Maldigestion and malabsorption of dietary lipid were determined as label losses in stools and stool lipid fractions whilst metabolic disposal was determined as label excretion on breath over the 10 hour postprandial period.
The results highlight differences between patients in the extent to which they may digest and absorb dietary lipid and the need to target the management according to causes of stool lipid losses. Whilst malabsorption was indicated in most patients, were patents appeared to have evidence of maldigestion. Thus, adjusting enzyme therapy has no advantages in patients who malabsorb dietary lipid and management should be focused on resolving malabsorption. Metabolism of absorbed lipid was altered in these patients and was due to a reduced oxidation of dietary lipid over the postprandial period. This altered metabolism may impact upon subsequent growth and body composition of patients and has implications for the use of breath tests in defining the capacity of gastrointestinal tract to digest and absorb dietary lipid. A model for the assessment and management of patients with weight loss or distributed growth was proposed.
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Published date: 2000
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Local EPrints ID: 466972
URI: http://eprints.soton.ac.uk/id/eprint/466972
PURE UUID: 5b3b8dc9-4a75-4303-ac05-33dc3457c68f
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Date deposited: 05 Jul 2022 08:05
Last modified: 16 Mar 2024 20:54
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Author:
Kirsi Marjut Laiho
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