Rowe, Brian Peter (1977) Some aspects of renin-angiotensin system. University of Southampton, Doctoral Thesis.
Abstract
Recently, the classical concept that angiotennin I is solely an inert precursor of the biologically active angiotensin II has been questioned. Some functions of angiotenein I are apparently independent of this conversion and, in this study, the possibility of a pressor role for angiotensin I has been investigated using conscious rabbits.In several situations, a qualitative di£farence between the mechanism of the pressor actions of angiotensins I and II has been shown. These include; tachyphylaxia to angiotensin II; barbiturate anaesthesia and alpha-adrenergic blockade with phentolamine. In contrast, there was no differential action of beta blockade, ganglion blockade and competitive inhibition with Sarl Glye angiotensin II on the two angiotensins. Studies on angiotenein I converting enzymes are also described. Evidence disputing the presupposed dominance of pulmonary conversion of angiotensin I to angiotenein II is presented. A converting enzyme antagonist.showed incomplete inhibition of the pressor response to angiotensin I. This supports the idea of 'a direct pressor action angiotensin. Preliminary work on an immunoelectrophoretic assay for renin is also reported. Plasma renin is currently measured as a function of its enzymic activity, and our understanding of the mechanisms governing the physiological expression of the renin-angiotensin system havebeen frustrated by a lack of information concerning plasma renin protein concentration. This problem could be circumvented using.an immune~ electrophoretic assay.
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