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Colponemids represent multiple ancient alveolate lineages

Colponemids represent multiple ancient alveolate lineages
Colponemids represent multiple ancient alveolate lineages
The alveolates comprise three well-studied protist lineages of significant environmental, medical, and economical importance: apicomplexans (e.g., Plasmodium), dinoflagellates (e.g., Symbiodinium), and ciliates (e.g., Tetrahymena). These major lineages have evolved distinct and unusual characteristics, the origins of which have proved to be difficult evolutionary puzzles. Mitochondrial genomes are a prime example: all three groups depart from canonical form and content, but in different ways. Reconstructing such ancient transitions is difficult without deep-branching lineages that retain ancestral characteristics. Here we describe two such lineages and how they illuminate the ancestral state of alveolate mitochondrial genomes. We established five clonal cultures of colponemids, predatory alveolates without cultured representatives and molecular data. Colponemids represent at least two independent lineages at the phylum level in multilocus phylogenetic analysis; one sister to apicomplexans and dinoflagellates, and the other at a deeper position. A genome survey from one strain showed that ancestral state of the mitochondrial genomes in the three major alveolate lineages consisted of an unusual linear chromosome with telomeres and a substantially larger gene set than known alveolates. Colponemid sequences also identified several environmental lineages as colponemids, altogether suggesting an untapped potential for understanding the origin and evolution of apicomplexans, dinoflagellates, and ciliates.
0960-9822
2456-2552
Janouškovec, J
fbaa4a5d-872e-465b-b2c3-bb35df455cc6
Tikhonenkov, DV
a1c998c0-e960-4269-b711-70f098020d96
Mikhailov, KV
e5b36cb8-f756-47e1-9b39-68746db8337d
Simdyanov, Timur G.
6ecfaba3-1c94-4602-a933-1805ea4b5e9d
Aleoshin, Vladimir V
96f45de0-b518-46fc-882f-c3f15ddb629a
Mylnikov, Alexander P.
ba6dced3-1dcf-4879-aca5-36782fceee35
Keeling, Patrick J.
fd51c2ef-1daa-442d-b186-71001aa7ca7d
Janouškovec, J
fbaa4a5d-872e-465b-b2c3-bb35df455cc6
Tikhonenkov, DV
a1c998c0-e960-4269-b711-70f098020d96
Mikhailov, KV
e5b36cb8-f756-47e1-9b39-68746db8337d
Simdyanov, Timur G.
6ecfaba3-1c94-4602-a933-1805ea4b5e9d
Aleoshin, Vladimir V
96f45de0-b518-46fc-882f-c3f15ddb629a
Mylnikov, Alexander P.
ba6dced3-1dcf-4879-aca5-36782fceee35
Keeling, Patrick J.
fd51c2ef-1daa-442d-b186-71001aa7ca7d

Janouškovec, J, Tikhonenkov, DV, Mikhailov, KV, Simdyanov, Timur G., Aleoshin, Vladimir V, Mylnikov, Alexander P. and Keeling, Patrick J. (2013) Colponemids represent multiple ancient alveolate lineages. Current Biology, 23 (24), 2456-2552. (doi:10.1016/j.cub.2013.10.062).

Record type: Article

Abstract

The alveolates comprise three well-studied protist lineages of significant environmental, medical, and economical importance: apicomplexans (e.g., Plasmodium), dinoflagellates (e.g., Symbiodinium), and ciliates (e.g., Tetrahymena). These major lineages have evolved distinct and unusual characteristics, the origins of which have proved to be difficult evolutionary puzzles. Mitochondrial genomes are a prime example: all three groups depart from canonical form and content, but in different ways. Reconstructing such ancient transitions is difficult without deep-branching lineages that retain ancestral characteristics. Here we describe two such lineages and how they illuminate the ancestral state of alveolate mitochondrial genomes. We established five clonal cultures of colponemids, predatory alveolates without cultured representatives and molecular data. Colponemids represent at least two independent lineages at the phylum level in multilocus phylogenetic analysis; one sister to apicomplexans and dinoflagellates, and the other at a deeper position. A genome survey from one strain showed that ancestral state of the mitochondrial genomes in the three major alveolate lineages consisted of an unusual linear chromosome with telomeres and a substantially larger gene set than known alveolates. Colponemid sequences also identified several environmental lineages as colponemids, altogether suggesting an untapped potential for understanding the origin and evolution of apicomplexans, dinoflagellates, and ciliates.

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More information

Accepted/In Press date: 23 October 2013
e-pub ahead of print date: 5 December 2013
Published date: 16 December 2013

Identifiers

Local EPrints ID: 467271
URI: http://eprints.soton.ac.uk/id/eprint/467271
ISSN: 0960-9822
PURE UUID: 748f9b25-7701-4a71-8379-63941fe61561
ORCID for J Janouškovec: ORCID iD orcid.org/0000-0001-6547-749X

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Date deposited: 05 Jul 2022 16:32
Last modified: 06 Jul 2022 02:13

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Contributors

Author: J Janouškovec ORCID iD
Author: DV Tikhonenkov
Author: KV Mikhailov
Author: Timur G. Simdyanov
Author: Vladimir V Aleoshin
Author: Alexander P. Mylnikov
Author: Patrick J. Keeling

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