Towards rabies elimination in Belgium by fox vaccination using a vaccinia-rabies glycoprotein recombinant virus
Towards rabies elimination in Belgium by fox vaccination using a vaccinia-rabies glycoprotein recombinant virus
Oral immunization of foxes by distributing vaccine baits was experimentally assessed and subsequently employed in the whole of the infected area of Belgium (10 000 km2). A vaccinia-rabies glycoprotein recombinant virus (VR-G) was used as vaccine because of its efficacy, safety and heat stability. Five ‘full’ campaigns of fox vaccination, carried out from 1989 until 1991, induced a drastic decrease in the incidence of rabies. The disease has disappeared from the major part of the initial infected area. In 1992 and 1993, three ‘defence’ campaigns, carried out along international borders, completely eliminated rabies virus infection from the fox population in 1993.
1368-1371
Brochier, B.
4722c29b-d33c-4f71-a850-f606017457e5
Boulanger, Denise
c226ad99-9c9a-485a-b480-42fb8799120f
Costy, Francoise
fbb87417-4e3d-4380-93da-241689eb3d9c
Pastoret, P.P.
ffb5a4df-e119-4396-9fc1-459327fa589d
January 1994
Brochier, B.
4722c29b-d33c-4f71-a850-f606017457e5
Boulanger, Denise
c226ad99-9c9a-485a-b480-42fb8799120f
Costy, Francoise
fbb87417-4e3d-4380-93da-241689eb3d9c
Pastoret, P.P.
ffb5a4df-e119-4396-9fc1-459327fa589d
Brochier, B., Boulanger, Denise, Costy, Francoise and Pastoret, P.P.
(1994)
Towards rabies elimination in Belgium by fox vaccination using a vaccinia-rabies glycoprotein recombinant virus.
Vaccine, 12 (15), .
(doi:10.1016/0264-410x(94)90143-0).
Abstract
Oral immunization of foxes by distributing vaccine baits was experimentally assessed and subsequently employed in the whole of the infected area of Belgium (10 000 km2). A vaccinia-rabies glycoprotein recombinant virus (VR-G) was used as vaccine because of its efficacy, safety and heat stability. Five ‘full’ campaigns of fox vaccination, carried out from 1989 until 1991, induced a drastic decrease in the incidence of rabies. The disease has disappeared from the major part of the initial infected area. In 1992 and 1993, three ‘defence’ campaigns, carried out along international borders, completely eliminated rabies virus infection from the fox population in 1993.
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Published date: January 1994
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Copyright © 1994 Published by Elsevier Ltd.
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Local EPrints ID: 467345
URI: http://eprints.soton.ac.uk/id/eprint/467345
ISSN: 0264-410X
PURE UUID: 8128816c-2dec-4974-8394-2d580e180fa5
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Date deposited: 06 Jul 2022 17:14
Last modified: 17 Mar 2024 02:57
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Contributors
Author:
B. Brochier
Author:
Denise Boulanger
Author:
Francoise Costy
Author:
P.P. Pastoret
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