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Trends in asthma incidence in children: a UK population-based cohort study

Trends in asthma incidence in children: a UK population-based cohort study
Trends in asthma incidence in children: a UK population-based cohort study
Background: Evidence suggests that asthma incidence has steadily declined in the past decade, especially in children. These trends have not been thoroughly explored across age groups in the UK.

Aim: To quantify recent trends in asthma incidence in a UK paediatric population using a large population-based cohort.

Methods: We identified 498,503 new asthma cases in patients aged 1-17 years contributing data to the Clinical Practice Research Datalink Aurum database from 1/1/07-31/12/19. We calculated annual asthma incidence rates for 3 different age groups (1-5, 6-11, 12-17), stratified by gender.

Results: Overall annual incidence rate fell continuously from 1,470 (95% CI;1449–1490) in 2007 to 634 (623–645) per 105 person years (pys) in 2019 (57% decline). Decline was similar between genders. The most pronounced decrease was in the 1-5 age group (Fig), in whom incidence dropped from 2813 (2762–2864) to 759 (735–783) per 105 pys (73% decline). The corresponding data for the 6-11 and 12-17 age group were 1156 (1126 – 1187) to 727 (707 – 747) (37% decline) and 550 (529 – 573) to 430 (415 – 447) (22% decline) per 105 pys, respectively.

Conclusion: The rate of new asthma diagnosis has fallen substantially in UK children since 2007. The pronounced decline in the 1-5 age group may be due to a change in diagnostic criteria for wheeze and asthma. Whilst there was some decrease in the 6-11 age group, incidence in 12-17year olds was relatively stable.
Asthma
0903-1936
Kallis, Constantinos
64f6a65e-1d82-46c0-a63a-41ddc6f03853
Morgan, Ann
385b8e0c-1f40-4afb-80d4-ab8dc781a0ae
Maslova, Ekaterina
79c024e0-5f69-4df1-8221-8ccd1a36fb23
Van der Valk, Ralf
80584764-978e-4204-92bd-e0eec12e000a
Tran, Trung N.
c425f11b-e9b6-49c5-88e8-6356e1cc9db3
Sinha, Ian P.
42c4c123-538f-467a-a6b6-9388a26c865f
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Quint, Jennifer K.
22800655-8987-4464-8385-7f08860c92f9
Kallis, Constantinos
64f6a65e-1d82-46c0-a63a-41ddc6f03853
Morgan, Ann
385b8e0c-1f40-4afb-80d4-ab8dc781a0ae
Maslova, Ekaterina
79c024e0-5f69-4df1-8221-8ccd1a36fb23
Van der Valk, Ralf
80584764-978e-4204-92bd-e0eec12e000a
Tran, Trung N.
c425f11b-e9b6-49c5-88e8-6356e1cc9db3
Sinha, Ian P.
42c4c123-538f-467a-a6b6-9388a26c865f
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Quint, Jennifer K.
22800655-8987-4464-8385-7f08860c92f9

Kallis, Constantinos, Morgan, Ann, Maslova, Ekaterina, Van der Valk, Ralf, Tran, Trung N., Sinha, Ian P., Roberts, Graham and Quint, Jennifer K. (2021) Trends in asthma incidence in children: a UK population-based cohort study. European Respiratory Journal, 58. (doi:10.1183/13993003.congress-2021.OA74).

Record type: Meeting abstract

Abstract

Background: Evidence suggests that asthma incidence has steadily declined in the past decade, especially in children. These trends have not been thoroughly explored across age groups in the UK.

Aim: To quantify recent trends in asthma incidence in a UK paediatric population using a large population-based cohort.

Methods: We identified 498,503 new asthma cases in patients aged 1-17 years contributing data to the Clinical Practice Research Datalink Aurum database from 1/1/07-31/12/19. We calculated annual asthma incidence rates for 3 different age groups (1-5, 6-11, 12-17), stratified by gender.

Results: Overall annual incidence rate fell continuously from 1,470 (95% CI;1449–1490) in 2007 to 634 (623–645) per 105 person years (pys) in 2019 (57% decline). Decline was similar between genders. The most pronounced decrease was in the 1-5 age group (Fig), in whom incidence dropped from 2813 (2762–2864) to 759 (735–783) per 105 pys (73% decline). The corresponding data for the 6-11 and 12-17 age group were 1156 (1126 – 1187) to 727 (707 – 747) (37% decline) and 550 (529 – 573) to 430 (415 – 447) (22% decline) per 105 pys, respectively.

Conclusion: The rate of new asthma diagnosis has fallen substantially in UK children since 2007. The pronounced decline in the 1-5 age group may be due to a change in diagnostic criteria for wheeze and asthma. Whilst there was some decrease in the 6-11 age group, incidence in 12-17year olds was relatively stable.

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More information

e-pub ahead of print date: 25 November 2021
Keywords: Asthma

Identifiers

Local EPrints ID: 467393
URI: http://eprints.soton.ac.uk/id/eprint/467393
ISSN: 0903-1936
PURE UUID: bf358dbb-e392-416d-9f98-7bfcd486f144
ORCID for Graham Roberts: ORCID iD orcid.org/0000-0003-2252-1248

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Date deposited: 07 Jul 2022 17:17
Last modified: 17 Mar 2024 03:02

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Contributors

Author: Constantinos Kallis
Author: Ann Morgan
Author: Ekaterina Maslova
Author: Ralf Van der Valk
Author: Trung N. Tran
Author: Ian P. Sinha
Author: Graham Roberts ORCID iD
Author: Jennifer K. Quint

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