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Keratinocyte cancer incidence report

Keratinocyte cancer incidence report
Keratinocyte cancer incidence report
Introduction The most common cancers in the UK are keratinocyte cancers (KCs): the combined term for basal cell carcinomas (BCC) and cutaneous squamous cell carcinomas (cSCC). Registration of KC is challenging due to high numbers and multiplicity of tumours per person.
Methods We provide an updated report on the descriptive epidemiology of trends in KC incidence for the resident populations of UK countries (England, Northern Ireland, Scotland and Wales) using population-based cancer registry and pathology report data, 2013-18.
Results Substantial increases in cSCC incidence in England, Scotland and Northern Ireland can be detected for the period of 2013-18, and the incidence of cSCC also increased in Wales from 2016-2018. In contrast, however, the pattern of annual change in the incidence of BCC across the nations differs. In England, the incidence of BCC declined slightly from 2016 to 2018 however the overall trend across 2013-18 is not statistically significant. In Scotland, the incidence of BCC shows some variability, declining in 2017 before increasing in 2018, and the overall trend across 2013-18 was also not statistically significant. In Northern Ireland, the incidence of BCC increased significantly over the study period, and in Wales, the incidence of BCC increased from 2016 to 2018. Approximately one in five people will develop NMSC in their lifetime in England. This estimate is much higher than the lifetime risk of melanoma (1 in 36 males and 1 in 47 females born after 1960 in the UK), which further highlights the burden of the disease and importance of early prevention strategies.
Conclusions We highlight how common these tumours are by publishing the first ever lifetime incidence of NMSC. Additionally, the first time reporting of the age standardised incidence of KC in Wales further confirms the scale of the disease burden posed by these cancers in the UK. With approximately one in five people developing NMSC in their lifetime, optimisation of skin cancer prevention, management and research are essential.
2690-442X
Ardern-Jones, Michael
7ac43c24-94ab-4d19-ba69-afaa546bec90
Ardern-Jones, Michael
7ac43c24-94ab-4d19-ba69-afaa546bec90

Ardern-Jones, Michael (2022) Keratinocyte cancer incidence report. Skin Health and Disease Open Access. (In Press)

Record type: Article

Abstract

Introduction The most common cancers in the UK are keratinocyte cancers (KCs): the combined term for basal cell carcinomas (BCC) and cutaneous squamous cell carcinomas (cSCC). Registration of KC is challenging due to high numbers and multiplicity of tumours per person.
Methods We provide an updated report on the descriptive epidemiology of trends in KC incidence for the resident populations of UK countries (England, Northern Ireland, Scotland and Wales) using population-based cancer registry and pathology report data, 2013-18.
Results Substantial increases in cSCC incidence in England, Scotland and Northern Ireland can be detected for the period of 2013-18, and the incidence of cSCC also increased in Wales from 2016-2018. In contrast, however, the pattern of annual change in the incidence of BCC across the nations differs. In England, the incidence of BCC declined slightly from 2016 to 2018 however the overall trend across 2013-18 is not statistically significant. In Scotland, the incidence of BCC shows some variability, declining in 2017 before increasing in 2018, and the overall trend across 2013-18 was also not statistically significant. In Northern Ireland, the incidence of BCC increased significantly over the study period, and in Wales, the incidence of BCC increased from 2016 to 2018. Approximately one in five people will develop NMSC in their lifetime in England. This estimate is much higher than the lifetime risk of melanoma (1 in 36 males and 1 in 47 females born after 1960 in the UK), which further highlights the burden of the disease and importance of early prevention strategies.
Conclusions We highlight how common these tumours are by publishing the first ever lifetime incidence of NMSC. Additionally, the first time reporting of the age standardised incidence of KC in Wales further confirms the scale of the disease burden posed by these cancers in the UK. With approximately one in five people developing NMSC in their lifetime, optimisation of skin cancer prevention, management and research are essential.

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Keratinocyte Cancer Incidence Report final version SHD - Accepted Manuscript
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Accepted/In Press date: 2022

Identifiers

Local EPrints ID: 467570
URI: http://eprints.soton.ac.uk/id/eprint/467570
ISSN: 2690-442X
PURE UUID: f9e8300f-2327-45dd-81e5-8f26194c707e
ORCID for Michael Ardern-Jones: ORCID iD orcid.org/0000-0003-1466-2016

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Date deposited: 14 Jul 2022 16:50
Last modified: 31 Aug 2022 04:01

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