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Tetrapyrrole synthesis of photosynthetic chromerids is likely homologous to the unusual pathway of apicomplexan parasites

Tetrapyrrole synthesis of photosynthetic chromerids is likely homologous to the unusual pathway of apicomplexan parasites
Tetrapyrrole synthesis of photosynthetic chromerids is likely homologous to the unusual pathway of apicomplexan parasites
Most photosynthetic eukaryotes synthesize both heme and chlorophyll via a common tetrapyrrole biosynthetic pathway starting from glutamate. This pathway was derived mainly from cyanobacterial predecessor of the plastid and differs from the heme synthesis of the plastid-lacking eukaryotes. Here, we show that the coral-associated alveolate Chromera velia, the closest known photosynthetic relative to Apicomplexa, possesses a tetrapyrrole pathway that is homologous to the unusual pathway of apicomplexan parasites. We also demonstrate that, unlike other eukaryotic phototrophs, Chromera synthesizes chlorophyll from glycine and succinyl-CoA rather than glutamate. Our data shed light on the evolution of the heme biosynthesis in parasitic Apicomplexa and photosynthesis-related biochemical processes in their ancestors.
1040-4651
3454–3462
Koreny, L
3fe2d512-d9f5-4bd7-810d-97f54a06ffe6
Sobotka, R
5587e889-8c14-47e7-bdf4-19191a9a5e12
Janouskovec, J
fbaa4a5d-872e-465b-b2c3-bb35df455cc6
Keeling, PJ
fd51c2ef-1daa-442d-b186-71001aa7ca7d
Oborník, M
2f082ea3-20ab-4cdf-b931-be97d5b3156e
Koreny, L
3fe2d512-d9f5-4bd7-810d-97f54a06ffe6
Sobotka, R
5587e889-8c14-47e7-bdf4-19191a9a5e12
Janouskovec, J
fbaa4a5d-872e-465b-b2c3-bb35df455cc6
Keeling, PJ
fd51c2ef-1daa-442d-b186-71001aa7ca7d
Oborník, M
2f082ea3-20ab-4cdf-b931-be97d5b3156e

Koreny, L, Sobotka, R, Janouskovec, J, Keeling, PJ and Oborník, M (2011) Tetrapyrrole synthesis of photosynthetic chromerids is likely homologous to the unusual pathway of apicomplexan parasites. The Plant Cell, 23 (9), 3454–3462. (doi:10.1105/tpc.111.089102).

Record type: Article

Abstract

Most photosynthetic eukaryotes synthesize both heme and chlorophyll via a common tetrapyrrole biosynthetic pathway starting from glutamate. This pathway was derived mainly from cyanobacterial predecessor of the plastid and differs from the heme synthesis of the plastid-lacking eukaryotes. Here, we show that the coral-associated alveolate Chromera velia, the closest known photosynthetic relative to Apicomplexa, possesses a tetrapyrrole pathway that is homologous to the unusual pathway of apicomplexan parasites. We also demonstrate that, unlike other eukaryotic phototrophs, Chromera synthesizes chlorophyll from glycine and succinyl-CoA rather than glutamate. Our data shed light on the evolution of the heme biosynthesis in parasitic Apicomplexa and photosynthesis-related biochemical processes in their ancestors.

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More information

Accepted/In Press date: 19 September 2011
e-pub ahead of print date: 30 September 2011
Published date: 30 September 2011
Additional Information: Copyright © 2011, Oxford University Press

Identifiers

Local EPrints ID: 467631
URI: http://eprints.soton.ac.uk/id/eprint/467631
ISSN: 1040-4651
PURE UUID: 9f0e8cec-20df-48ff-bd13-3b4cf7fc774d
ORCID for J Janouskovec: ORCID iD orcid.org/0000-0001-6547-749X

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Date deposited: 15 Jul 2022 19:23
Last modified: 19 Jul 2022 02:13

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Contributors

Author: L Koreny
Author: R Sobotka
Author: J Janouskovec ORCID iD
Author: PJ Keeling
Author: M Oborník

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