Paediatric health-related quality of life in congenital cytomegalovirus
Paediatric health-related quality of life in congenital cytomegalovirus
Objective: congenital cytomegalovirus (cCMV) is the most common congenital infection globally. This cross-sectional study aimed to describe the health-related quality of life (HRQoL) of children with cCMV and that of their parents.
Methods: families of children with cCMV in the UK were approached through the charity CMV Action. Parents completed questionnaires about their own HRQoL and that of their child. Children who were able to self-report completed questionnaires about their own HRQoL. Demographic characteristics of the sample were described using descriptive statistics. Questionnaire responses were scored, and domain and summary scores were calculated and compared with UK population norms, where available.
Results: seventy families participated, with children aged between 5 months and 18 years. Children with cCMV had poorer HRQoL compared with children from UK population data. HRQoL of children whose health was more severely affected by cCMV was poorer than that of children whose health was less severely affected. Parents of children whose health was moderately or severely affected had greater psychological morbidity and poorer HRQoL in physical, emotional, social, and cognitive functioning domains than parents of less severely affected children.
Conclusions: cCMV has a significant effect on the HRQoL of children with cCMV and their parents, with the children with the most significant health needs having the lowest HRQoL compared with those children with little or no effects on their health. This data could contribute to health economic analyses, informing resource allocation to potential interventions for the prevention and treatment of cCMV.
Child Health, Communicable Diseases, Infectious Disease Medicine, Paediatrics
1004-1011
Ralph, Kate Monica Isabel
2cb60c94-4f9f-421c-9c62-505fcae39dfc
Bull, Kim
751f8b25-29ba-4d4f-96e2-6c339a83a47f
Trotter, Caroline
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Wood, Sharon
978db8aa-eef1-4210-99c3-14b291c9a2cc
Jones, Christine E
48229079-8b58-4dcb-8374-d9481fe7b426
November 2022
Ralph, Kate Monica Isabel
2cb60c94-4f9f-421c-9c62-505fcae39dfc
Bull, Kim
751f8b25-29ba-4d4f-96e2-6c339a83a47f
Trotter, Caroline
c3e5fd54-24a0-4913-9110-3cfcf4eb95ce
Wood, Sharon
978db8aa-eef1-4210-99c3-14b291c9a2cc
Jones, Christine E
48229079-8b58-4dcb-8374-d9481fe7b426
Ralph, Kate Monica Isabel, Bull, Kim, Trotter, Caroline, Wood, Sharon and Jones, Christine E
(2022)
Paediatric health-related quality of life in congenital cytomegalovirus.
Archives of Disease in Childhood, 107 (11), .
(doi:10.1136/archdischild-2022-324007).
Abstract
Objective: congenital cytomegalovirus (cCMV) is the most common congenital infection globally. This cross-sectional study aimed to describe the health-related quality of life (HRQoL) of children with cCMV and that of their parents.
Methods: families of children with cCMV in the UK were approached through the charity CMV Action. Parents completed questionnaires about their own HRQoL and that of their child. Children who were able to self-report completed questionnaires about their own HRQoL. Demographic characteristics of the sample were described using descriptive statistics. Questionnaire responses were scored, and domain and summary scores were calculated and compared with UK population norms, where available.
Results: seventy families participated, with children aged between 5 months and 18 years. Children with cCMV had poorer HRQoL compared with children from UK population data. HRQoL of children whose health was more severely affected by cCMV was poorer than that of children whose health was less severely affected. Parents of children whose health was moderately or severely affected had greater psychological morbidity and poorer HRQoL in physical, emotional, social, and cognitive functioning domains than parents of less severely affected children.
Conclusions: cCMV has a significant effect on the HRQoL of children with cCMV and their parents, with the children with the most significant health needs having the lowest HRQoL compared with those children with little or no effects on their health. This data could contribute to health economic analyses, informing resource allocation to potential interventions for the prevention and treatment of cCMV.
Text
Ralph 2022 Paediatric HRQoL in cCMV (Arch Dis Child) accepted manuscript (1)
- Accepted Manuscript
More information
Accepted/In Press date: 22 June 2022
e-pub ahead of print date: 29 June 2022
Published date: November 2022
Additional Information:
Funding Information:
Finally, Kate Ralph is extremely grateful for the financial support that she received through the Dr Sanderson Scholarship to fund her studies this year.
Funding Information:
CEJ runs clinical trials of vaccines in pregnancy funded by vaccine manufactures; all funding is paid to her institution. She has received payment from Pfizer, MSD and Sanofi Pasteur for consultancy or advisory boards related to vaccination in pregnancy.
Publisher Copyright:
©
Keywords:
Child Health, Communicable Diseases, Infectious Disease Medicine, Paediatrics
Identifiers
Local EPrints ID: 467672
URI: http://eprints.soton.ac.uk/id/eprint/467672
ISSN: 0003-9888
PURE UUID: 018cc635-eaff-4937-8354-e2dea75e68e6
Catalogue record
Date deposited: 19 Jul 2022 16:36
Last modified: 17 Mar 2024 03:45
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Contributors
Author:
Kate Monica Isabel Ralph
Author:
Caroline Trotter
Author:
Sharon Wood
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