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Early biochemical observations point to nutritional strategies to manage non-alcoholic fatty liver disease

Early biochemical observations point to nutritional strategies to manage non-alcoholic fatty liver disease
Early biochemical observations point to nutritional strategies to manage non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disease globally. The first stage of NAFLD is steatosis, the accumulation of triacylglycerols within hepatocytes. Inflammation and oxidative stress both contribute to progression to more severe disease. In 2004 Clinical Science published two papers reporting on fatty acids and oxidative stress markers in the livers of patients with NAFLD; both these papers are highly cited. One paper reported an altered pattern of fatty acids within the livers of patients with NAFLD; there was a lower contribution of polyunsaturated fatty acids (PUFAs) including both n - 6 and n - 3 PUFAs and an altered balance between n - 6 and n - 3 PUFAs in favour of the former. Ratios of precursor PUFAs to their long chain more unsaturated derivatives were altered in NAFLD and were interpreted to indicate a reduced activity of the pathway of synthesis of long chain highly unsaturated PUFAs. The authors interpreted their findings to indicate that a low hepatic content of n - 3 PUFAs has a causal role in NAFLD. The second paper reported lower hepatic antioxidant defences and increased markers of oxidative stress in NAFLD, consistent with a role for oxidative stress in the disease. Many studies have now explored the effect of supplemental n - 3 PUFAs or antioxidants, including vitamin E, in patients with NAFLD with some benefits being reported. There remains much interest in n - 3 PUFAs and antioxidants as preventive and therapeutic strategies in NAFLD and therefore it seems likely that citation of the two papers from 2004 will be sustained.


Antioxidant, Fatty liver, NAFLD, Omega-3 fatty acid, Oxidative stress, Polyunsaturated fatty acid
0143-5221
1019–1023
Calder, Philip
1797e54f-378e-4dcb-80a4-3e30018f07a6
Calder, Philip
1797e54f-378e-4dcb-80a4-3e30018f07a6

Calder, Philip (2022) Early biochemical observations point to nutritional strategies to manage non-alcoholic fatty liver disease. Clinical Science, 136 (13), 1019–1023. (doi:10.1042/CS20220380).

Record type: Letter

Abstract

Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disease globally. The first stage of NAFLD is steatosis, the accumulation of triacylglycerols within hepatocytes. Inflammation and oxidative stress both contribute to progression to more severe disease. In 2004 Clinical Science published two papers reporting on fatty acids and oxidative stress markers in the livers of patients with NAFLD; both these papers are highly cited. One paper reported an altered pattern of fatty acids within the livers of patients with NAFLD; there was a lower contribution of polyunsaturated fatty acids (PUFAs) including both n - 6 and n - 3 PUFAs and an altered balance between n - 6 and n - 3 PUFAs in favour of the former. Ratios of precursor PUFAs to their long chain more unsaturated derivatives were altered in NAFLD and were interpreted to indicate a reduced activity of the pathway of synthesis of long chain highly unsaturated PUFAs. The authors interpreted their findings to indicate that a low hepatic content of n - 3 PUFAs has a causal role in NAFLD. The second paper reported lower hepatic antioxidant defences and increased markers of oxidative stress in NAFLD, consistent with a role for oxidative stress in the disease. Many studies have now explored the effect of supplemental n - 3 PUFAs or antioxidants, including vitamin E, in patients with NAFLD with some benefits being reported. There remains much interest in n - 3 PUFAs and antioxidants as preventive and therapeutic strategies in NAFLD and therefore it seems likely that citation of the two papers from 2004 will be sustained.


Text
Calder_Clin Sci Commentary_Revised - Accepted Manuscript
Restricted to Repository staff only until 1 July 2023.
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More information

Accepted/In Press date: 20 June 2022
Published date: 1 July 2022
Keywords: Antioxidant, Fatty liver, NAFLD, Omega-3 fatty acid, Oxidative stress, Polyunsaturated fatty acid

Identifiers

Local EPrints ID: 467682
URI: http://eprints.soton.ac.uk/id/eprint/467682
ISSN: 0143-5221
PURE UUID: f3b21c2c-6882-4480-9090-03b01d238725
ORCID for Philip Calder: ORCID iD orcid.org/0000-0002-6038-710X

Catalogue record

Date deposited: 19 Jul 2022 16:41
Last modified: 23 Jul 2022 01:40

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