A co-conformationally “topologically” chiral catenane

Rubio, Arnau, Rodriguez, Savoini, Andrea, Modicom, Florian, Butler, Patrick, Walter Villers and Goldup, Stephen (2022) A co-conformationally “topologically” chiral catenane. Journal of the American Chemical Society, 144 (27), 11927–11932. (doi:10.1021/jacs.2c02029).

Record type: Article

Abstract

Catenanes composed of two achiral rings that are oriented (Cnh symmetry) because of the sequence of atoms they contain are referred to as topologically chiral. Here we present the synthesis of a highly enantioenriched catenane containing a related but overlooked “co-conformationally ‘topologically’ chiral” stereo-genic unit, which arises when a bilaterally symmetric Cnv ring is desymmetrised by the position of an oriented macrocycle.

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Accepted/In Press date: 20 June 2022

e-pub ahead of print date: 28 June 2022

Published date: 28 June 2022

Additional Information: Funding Information: S.M.G. thanks the ERC (Agreement No. 724987) for funding and the Royal Society for a Wolfson Research Fellowship (RSWF\FT\180010). P.B. thanks the University of Southampton for a Presidential Scholarship. F.M. thanks the ESPRC for a Doctoral Prize Scholarship (EP/R513325/1). Publisher Copyright: © 2022 American Chemical Society. All rights reserved.

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