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Adipocyte-Specific Fatty Acid-Binding Protein (AFABP) and Chemerin in Association with Gestational Diabetes: A case-control study

Adipocyte-Specific Fatty Acid-Binding Protein (AFABP) and Chemerin in Association with Gestational Diabetes: A case-control study
Adipocyte-Specific Fatty Acid-Binding Protein (AFABP) and Chemerin in Association with Gestational Diabetes: A case-control study

Background. Adipocytokines participate in regulating the inflammatory response in glucose homeostasis and type 2 diabetes. However, among these peptides, the role of adipocyte-specific fatty-acid-binding protein (AFABP), chemerin, and secreted protein acidic and rich in cysteine (SPARC) in gestational diabetes (GDM) has not been fully investigated. 


Method. The maternal fasting level of adipocytokines of 53 subjects with GDM and 43 normal pregnant (NGDM) was measured using multiplex immunoassay at 24-28 weeks, before delivery, immediate postpartum, and 2-6 months postpuerperium. 

Results. Higher levels of AFABP were associated with a 3.7-fold higher risk of GDM. Low chemerin levels were associated with a 3.6-fold higher risk of GDM. Interleukin-10 (IL-10) was inversely associated with the risk of GDM. SPARC had no association with GDM. AFABP was directly correlated to interleukin-6 (r=0.50), insulin resistance index (r=0.26), and body mass index (r=0.28) and inversely correlated to C-reactive protein (r=-0.27). Chemerin levels were directly and strongly correlated with IL-10 (r=0.41) and interleukin-4 (r=0.50) and inversely correlated to insulin resistance index (r=-0.23) in GDM but not NGDM. In the longitudinal assessment, there were no significant differences in AFABP and chemerin concentrations of both studied groups. Conclusion. AFABP and chemerin were associated with a higher risk of GDM. These adipocytokines were related to insulin resistance, body mass index, and inflammation in pregnant women diagnosed with GDM.

2314-6745
1-7
Mosavat, Maryam
6542e3ee-d2da-4087-a1c1-10bfc1f87c98
Mirsanjari, Mitra
1d4dcf46-a52c-4c7e-af49-fc673d0485d7
Lwaleed, Bashir A.
e7c59131-82ad-4a14-a227-7370e91e3f21
Kamarudin, Maherah
0e52d4e4-91d3-43b1-9f1f-73dea35984a2
Omar, Siti Zawiah
f88b406c-2266-408f-b0b9-9a4b5b89c669
Mosavat, Maryam
6542e3ee-d2da-4087-a1c1-10bfc1f87c98
Mirsanjari, Mitra
1d4dcf46-a52c-4c7e-af49-fc673d0485d7
Lwaleed, Bashir A.
e7c59131-82ad-4a14-a227-7370e91e3f21
Kamarudin, Maherah
0e52d4e4-91d3-43b1-9f1f-73dea35984a2
Omar, Siti Zawiah
f88b406c-2266-408f-b0b9-9a4b5b89c669

Mosavat, Maryam, Mirsanjari, Mitra, Lwaleed, Bashir A., Kamarudin, Maherah and Omar, Siti Zawiah (2021) Adipocyte-Specific Fatty Acid-Binding Protein (AFABP) and Chemerin in Association with Gestational Diabetes: A case-control study. Journal of Diabetes Research, 2021, 1-7, [5533802]. (doi:10.1155/2021/5533802).

Record type: Article

Abstract

Background. Adipocytokines participate in regulating the inflammatory response in glucose homeostasis and type 2 diabetes. However, among these peptides, the role of adipocyte-specific fatty-acid-binding protein (AFABP), chemerin, and secreted protein acidic and rich in cysteine (SPARC) in gestational diabetes (GDM) has not been fully investigated. 


Method. The maternal fasting level of adipocytokines of 53 subjects with GDM and 43 normal pregnant (NGDM) was measured using multiplex immunoassay at 24-28 weeks, before delivery, immediate postpartum, and 2-6 months postpuerperium. 

Results. Higher levels of AFABP were associated with a 3.7-fold higher risk of GDM. Low chemerin levels were associated with a 3.6-fold higher risk of GDM. Interleukin-10 (IL-10) was inversely associated with the risk of GDM. SPARC had no association with GDM. AFABP was directly correlated to interleukin-6 (r=0.50), insulin resistance index (r=0.26), and body mass index (r=0.28) and inversely correlated to C-reactive protein (r=-0.27). Chemerin levels were directly and strongly correlated with IL-10 (r=0.41) and interleukin-4 (r=0.50) and inversely correlated to insulin resistance index (r=-0.23) in GDM but not NGDM. In the longitudinal assessment, there were no significant differences in AFABP and chemerin concentrations of both studied groups. Conclusion. AFABP and chemerin were associated with a higher risk of GDM. These adipocytokines were related to insulin resistance, body mass index, and inflammation in pregnant women diagnosed with GDM.

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Accepted/In Press date: 21 April 2021
Published date: 28 April 2021
Additional Information: Copyright © 2021 Maryam Mosavat et al.

Identifiers

Local EPrints ID: 468071
URI: http://eprints.soton.ac.uk/id/eprint/468071
ISSN: 2314-6745
PURE UUID: 1034ac93-501b-4b68-bdaa-2c4988330e10

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Date deposited: 29 Jul 2022 16:42
Last modified: 29 Jul 2022 16:42

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Author: Maryam Mosavat
Author: Mitra Mirsanjari
Author: Maherah Kamarudin
Author: Siti Zawiah Omar

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