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Miniature fiber optic surface plasmon resonance biosensor

Miniature fiber optic surface plasmon resonance biosensor
Miniature fiber optic surface plasmon resonance biosensor
A novel design of surface plasmon resonance fiber optic sensor is reported which leads to a compact, highly miniaturized sensing element with excellent sensitivity. The sensing device is based on a side-polished single-mode optical fiber with a thin metal overlayer supporting surface plasmon waves. The strength of interaction between a fiber mode and a surface plasmon wave depends strongly on the refractive index near the sensing surface. Therefore refractive index changes associated with biospecific interaction between antibodies immobilized on the sensor and antigen molecules can be monitored by measuring light intensity variations. Detection of horse radish peroxidase (HRP) of the concentration of 100 ng/ml has been accomplished using the fiber optic sensor with a matrix of monoclonal antibodies against HRP immobilized on the sensor surface.
0277-786X
184-191
Bellingham, SPIE
Slavík, Radan
2591726a-ecc0-4d1a-8e1d-4d0fd8da8f7d
Brynda, Eduard
fbdfe905-9aa5-41d5-a894-94fbc3960294
Homola, Jiří
9ae778bd-5e0d-4e3c-9597-17409470a575
Čtyroký, Jiří
1a8cfc78-d014-48d6-a2b5-b9764f7a859a
Slavík, Radan
2591726a-ecc0-4d1a-8e1d-4d0fd8da8f7d
Brynda, Eduard
fbdfe905-9aa5-41d5-a894-94fbc3960294
Homola, Jiří
9ae778bd-5e0d-4e3c-9597-17409470a575
Čtyroký, Jiří
1a8cfc78-d014-48d6-a2b5-b9764f7a859a

Slavík, Radan, Brynda, Eduard, Homola, Jiří and Čtyroký, Jiří (1999) Miniature fiber optic surface plasmon resonance biosensor. In Proceedings of the 1998 Biomedical Sensors, Fibers, and Optical Delivery Systems. vol. 3570, Bellingham, SPIE. pp. 184-191 . (doi:10.1117/12.336929).

Record type: Conference or Workshop Item (Paper)

Abstract

A novel design of surface plasmon resonance fiber optic sensor is reported which leads to a compact, highly miniaturized sensing element with excellent sensitivity. The sensing device is based on a side-polished single-mode optical fiber with a thin metal overlayer supporting surface plasmon waves. The strength of interaction between a fiber mode and a surface plasmon wave depends strongly on the refractive index near the sensing surface. Therefore refractive index changes associated with biospecific interaction between antibodies immobilized on the sensor and antigen molecules can be monitored by measuring light intensity variations. Detection of horse radish peroxidase (HRP) of the concentration of 100 ng/ml has been accomplished using the fiber optic sensor with a matrix of monoclonal antibodies against HRP immobilized on the sensor surface.

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More information

Published date: 15 January 1999
Venue - Dates: Proceedings of the 1998 Biomedical Sensors, Fibers, and Optical Delivery Systems, , Stockholm, SWE, 1998-09-08 - 1998-09-10

Identifiers

Local EPrints ID: 468186
URI: http://eprints.soton.ac.uk/id/eprint/468186
ISSN: 0277-786X
PURE UUID: d00d69c2-1f10-4baa-9952-20e8db79f2b4
ORCID for Radan Slavík: ORCID iD orcid.org/0000-0002-9336-4262

Catalogue record

Date deposited: 04 Aug 2022 16:46
Last modified: 05 Aug 2022 01:42

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Contributors

Author: Radan Slavík ORCID iD
Author: Eduard Brynda
Author: Jiří Homola
Author: Jiří Čtyroký

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