Individualized analysis of skin thermosensory thresholds and sensitivity in heat-sensitive people with multiple sclerosis
Individualized analysis of skin thermosensory thresholds and sensitivity in heat-sensitive people with multiple sclerosis
We investigated whether and how multiple sclerosis (MS) alters thresholds for perceiving increases and decreases in local skin temperature, as well as the sensitivity to progressively greater temperature stimuli, amongst heat-sensitive people with MS. Eleven MS patients (5 M/6 F; 51.1 ± 8.6 y, EDSS 5.7 ± 1.9) and 11 healthy controls (CTR; 7 M/4 F; 50.3 ± 9.0 y) performed warm and cold threshold tests on a hairy skin site, on both sides of the body. They also underwent a thermosensitivity test where they rated (visual analogue scale) perceived magnitude of 4 local skin stimuli (i.e. 22, 26, 34, 38°C). Individual thresholds and slopes of linear regression for thermosensitivity were z-transformed for each MS patient, and used to determine individual thermosensory abnormalities. When considering both threshold and thermosensitivity, six out of our 11 heat-sensitive patients (54.5%) exhibited skin thermosensory abnormalities. Those abnormalities varied amongst patients in terms of type (threshold vs. thermosensitivity), quality (warm vs. cold), location (left vs. right side of the body) and extent. Each of those six patients presented unique thermosensory profiles. While some patients experienced thermosensory loss in both thresholds and sensitivity and on both sides of the body, others experienced cold thermosensory loss on one side of the body only. The observed individual variability in thermosensory function among heat-sensitive MS patients highlight the need for a patient-centered approach to assessing thermosensory dysfunction and its potential implications for heat stress vulnerability in this patient group.
21-29
Filingeri, Davide
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Chaseling, Georgia
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Christogianni, Aikaterini
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Feka, Kaltrina
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Bianco, Antonino
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Davis, Scott L
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Jay, Ollie
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24 May 2020
Filingeri, Davide
42502a34-e7e6-4b49-b304-ce2ae0bf7b24
Chaseling, Georgia
34771262-b371-4d37-b631-e60d5e65d752
Christogianni, Aikaterini
696c8a6c-30d6-4fb1-b7e4-70d45997180b
Feka, Kaltrina
659e68a7-e48d-4f86-9226-48a7a20708ef
Bianco, Antonino
c813a96b-983f-438f-8ee8-36c67746e727
Davis, Scott L
8cacbc30-25be-492f-bf2c-8577f0bb3978
Jay, Ollie
2e255cfd-1fc6-4ce7-891d-4fcba88c0250
Filingeri, Davide, Chaseling, Georgia, Christogianni, Aikaterini, Feka, Kaltrina, Bianco, Antonino, Davis, Scott L and Jay, Ollie
(2020)
Individualized analysis of skin thermosensory thresholds and sensitivity in heat-sensitive people with multiple sclerosis.
Temperature, 8 (1), .
(doi:10.1080/23328940.2020.1769007).
Abstract
We investigated whether and how multiple sclerosis (MS) alters thresholds for perceiving increases and decreases in local skin temperature, as well as the sensitivity to progressively greater temperature stimuli, amongst heat-sensitive people with MS. Eleven MS patients (5 M/6 F; 51.1 ± 8.6 y, EDSS 5.7 ± 1.9) and 11 healthy controls (CTR; 7 M/4 F; 50.3 ± 9.0 y) performed warm and cold threshold tests on a hairy skin site, on both sides of the body. They also underwent a thermosensitivity test where they rated (visual analogue scale) perceived magnitude of 4 local skin stimuli (i.e. 22, 26, 34, 38°C). Individual thresholds and slopes of linear regression for thermosensitivity were z-transformed for each MS patient, and used to determine individual thermosensory abnormalities. When considering both threshold and thermosensitivity, six out of our 11 heat-sensitive patients (54.5%) exhibited skin thermosensory abnormalities. Those abnormalities varied amongst patients in terms of type (threshold vs. thermosensitivity), quality (warm vs. cold), location (left vs. right side of the body) and extent. Each of those six patients presented unique thermosensory profiles. While some patients experienced thermosensory loss in both thresholds and sensitivity and on both sides of the body, others experienced cold thermosensory loss on one side of the body only. The observed individual variability in thermosensory function among heat-sensitive MS patients highlight the need for a patient-centered approach to assessing thermosensory dysfunction and its potential implications for heat stress vulnerability in this patient group.
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23328940.2020
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Accepted/In Press date: 11 May 2020
Published date: 24 May 2020
Additional Information:
© 2020 Informa UK Limited, trading as Taylor & Francis Group.
Identifiers
Local EPrints ID: 468188
URI: http://eprints.soton.ac.uk/id/eprint/468188
ISSN: 2332-8940
PURE UUID: 50683484-0bfb-4064-8f1e-a75412baf460
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Date deposited: 04 Aug 2022 16:51
Last modified: 17 Mar 2024 04:05
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Contributors
Author:
Georgia Chaseling
Author:
Aikaterini Christogianni
Author:
Kaltrina Feka
Author:
Antonino Bianco
Author:
Scott L Davis
Author:
Ollie Jay
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