Allergic sensitization trajectories to age 8 years in the Singapore GUSTO cohort

Accepted/In Press date: 15 June 2022

e-pub ahead of print date: 14 July 2022

Published date: July 2022

Additional Information: Funding Information: This research is supported by the Singapore National Research Foundation under its Translational and Clinical Research (TCR) Flagship Programme and administered by the Singapore Ministry of Health's National Medical Research Council (NMRC), Singapore - NMRC/TCR/004-NUS/2008; NMRC/TCR/012-NUHS/2014. Additional funding is provided by the Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A∗STAR), Singapore. EH Tham is supported by the National Medical Research Council (NMRC) Transition Award grant [MOH-TA18nov-003] from NMRC, Singapore. Godfrey KM is supported by the UK Medical Research Council (MC_UU_12011/4), the National Institute for Health Research (NIHR Senior Investigator (NF-SI-0515-10042) and NIHR Southampton Biomedical Research Centre (IS-BRC-1215-20004)), the European Union (Erasmus + Programme ImpENSA 598488-EPP-1-2018-1-DE-EPPKA2-CBHE-JP) and the British Heart Foundation (RG/15/17/3174, SP/F/21/150013). All authors declare that the study sponsors had no role in the study design, collection, analysis and interpretation of data, in the writing of the report and in the decision to submit the article for publication. Funding Information: Early onset eczema by six months was associated with both EFMS and LMS. Our result is supported by the Melbourne Atopy Cohort Study which also reported that early eczema by six months preceded and predicted allergic sensitization at one year. 24 Recently, the “outside-in” hypothesis, which postulates that early onset of eczema increases susceptibility to transcutaneous sensitization by allergens and initiates the atopic march leading to asthma and rhinitis, has gained attention. 25 Eczema with filaggrin mutations, a key gene in the skin barrier, has been associated with skin barrier integrity and degree of inhalant allergic sensitization, while such associations were not found for children with eczema who did not have filaggrin mutations. 26 Allergic sensitization can in turn increase the risk of having subsequent eczema later in childhood. 4 The Danish Allergy Research Centre cohort showed that, similar to our study, development of subsequent atopic dermatitis at age six years was associated with early food and inhalant sensitization and early atopic dermatitis from 0 to 18 months. 27 Funding Information: We thank the GUSTO study group and all clinical and home-visit staff involved. The voluntary participation of all subjects is greatly appreciated. The GUSTO study group includes Allan Sheppard, Amutha Chinnadurai, Anne Eng Neo Goh, Anne Rifkin-Graboi, Anqi Qiu, Arijit Biswas, Bee Wah Lee, Birit Froukje Philipp Broekman, Boon Long Quah, Chai Kiat Chng, Cheryl Shufen Ngo, Choon Looi Bong, Christiani Jeyakumar Henry, Daniel Yam Thiam Goh, Doris Ngiuk Lan Loh, Evelyn Xiu Ling Loo, Elizabeth Huiwen Tham, Fabian Kok Peng Yap, George Seow Heong Yeo, Helen Yu Chen, Hugo P S van Bever, Iliana Magiati, Inez Bik Yun Wong, Ivy Yee-Man Lau, Jeevesh Kapur, Jenny L. Richmond, Jerry Kok Yen Chan, Joanna Dawn Holbrook, Joshua J. Gooley, Karen Tan Mei Ling, Keith M. Godfrey, Kenneth Yung Chiang Kwek, Kok Hian Tan, Krishnamoorthy Naiduvaje, Leher Singh, Lin Lin Su, Lourdes Mary Daniel, Lynette Pei-Chi Shek, Marielle V. Fortier, Mark Hanson, Mary Foong-Fong Chong, Mary Rauff, Mei Chien Chua, Michael J. Meaney, Mya Thway Tint, Neerja Karnani, Ngee Lek, Oon Hoe Teoh, P. C. Wong, Peter David Gluckman, Pratibha Keshav Agarwal, Rob Martinus van Dam, Salome A. Rebello, Seang Mei Saw, Shang Chee Chong, Shirong Cai, Shu-E Soh, Sok Bee Lim, Stephen Chin-Ying Hsu, Victor Samuel Rajadurai, Walter Stunkel, Wee Meng Han, Wei Wei Pang, Yap Seng Chong, Yin Bun Cheung, Yiong Huak Chan and Yung Seng Lee. Publisher Copyright: © 2022 The Authors

Keywords: Allergic sensitization trajectories, Eczema, House dust mite, Latent class analysis, Wheeze

Local EPrints ID: 468311

URI: http://eprints.soton.ac.uk/id/eprint/468311

DOI: doi:10.1016/j.waojou.2022.100667

ISSN: 1939-4551

PURE UUID: 7510def2-ee99-4b2c-96bd-ddc0b1d899ad

ORCID for Keith Godfrey: orcid.org/0000-0002-4643-0618

Date deposited: 10 Aug 2022 16:32

Last modified: 17 Mar 2024 02:38