READ ME File For 'The Influence of Germline Genotype on Breast Cancer Tumour Phenotype'

Dataset DOI: 10.5258/SOTON/D1618

ReadMe Author: Stephanie Leanne Greville-Heygate, University of Southampton ORCID ID

This dataset supports the thesis entitled The Impact of Germline Genotype on Breast Cancer Tumour Phenotype and Outcome
AWARDED BY: University of Southampton
DATE OF AWARD: [2021]

DESCRIPTION OF THE DATA
Summary level data derived from The 100,000 Genomes Project, Rare Disease, Familial Breast Cancer and Cancer, Breast Cancer Recruitment Domains. Data exported via the Genomics England secure AirLock system. This includes the number of pathogenic/likely pathogenic variant identified in BRCA, PALB2, CHEK2, ATM and TP53. It compares the age of cancer onset between gene carriers and non-carriers. It also compares the Tumour Mutational Burden, Somatic Mutational Signature and Somatic Mutational Profile between gene carriers and non-carriers.

Date of data collection: [November 2017- November 2020]

Information about geographic location of data collection: 

Licence:CC-BY
Date that the file was created: August, 2022

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