Plasmodium vivax malaria in the common marmoset, Callithrix jacchus: adaptation and host response to infection
Plasmodium vivax malaria in the common marmoset, Callithrix jacchus: adaptation and host response to infection
Infection with Plasmodium vivax was established in splenectomized Callithrix jacchus marmosets by inoculation of parasitized blood from Aotus trivirgatus carrying the Vietnam Palo-Alto line of P. vivax. Subsequent blood passage through intact marmosets resulted in higher peak parasitaemias (about 1% of red cells infected) and the loss of stainable Schüffner's dots in infected cells. Primary infections with the adapted line were patent for 74 days or more, and induced both a substantial antibody response, as determined by indirect fluorescence, and some lymphocytosis, but no marked anaemia. Marmosets which had recovered from their primary infection (or in which it was drug-cured) suffered abbreviated patency with low-grade parasitaemia on re-infection.
Animals, Antibodies, Protozoan/analysis, Callithrix/parasitology, Callitrichinae/parasitology, Disease Models, Animal, Female, Fluorescent Antibody Technique, Immunoglobulin G/analysis, Leukocyte Count, Malaria/immunology, Male, Plasmodium vivax, Splenectomy
241-50
Mitchell, G H
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Johnston, D A
b41163c9-b9d2-425c-af99-2a357204014e
Naylor, B A
bb2b9152-518a-42e0-af74-063aa8d99397
Knight, A M
7f52e634-0d53-4305-86fb-ee5913c682da
Wedderburn, N
478d50f1-a7bb-479d-9b19-b8030531f77f
April 1988
Mitchell, G H
f45cae8f-b55d-407c-adc7-34dc7beb36f5
Johnston, D A
b41163c9-b9d2-425c-af99-2a357204014e
Naylor, B A
bb2b9152-518a-42e0-af74-063aa8d99397
Knight, A M
7f52e634-0d53-4305-86fb-ee5913c682da
Wedderburn, N
478d50f1-a7bb-479d-9b19-b8030531f77f
Mitchell, G H, Johnston, D A, Naylor, B A, Knight, A M and Wedderburn, N
(1988)
Plasmodium vivax malaria in the common marmoset, Callithrix jacchus: adaptation and host response to infection.
Parasitology, 96 ( Pt 2), .
(doi:10.1017/s0031182000058248).
Abstract
Infection with Plasmodium vivax was established in splenectomized Callithrix jacchus marmosets by inoculation of parasitized blood from Aotus trivirgatus carrying the Vietnam Palo-Alto line of P. vivax. Subsequent blood passage through intact marmosets resulted in higher peak parasitaemias (about 1% of red cells infected) and the loss of stainable Schüffner's dots in infected cells. Primary infections with the adapted line were patent for 74 days or more, and induced both a substantial antibody response, as determined by indirect fluorescence, and some lymphocytosis, but no marked anaemia. Marmosets which had recovered from their primary infection (or in which it was drug-cured) suffered abbreviated patency with low-grade parasitaemia on re-infection.
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Published date: April 1988
Keywords:
Animals, Antibodies, Protozoan/analysis, Callithrix/parasitology, Callitrichinae/parasitology, Disease Models, Animal, Female, Fluorescent Antibody Technique, Immunoglobulin G/analysis, Leukocyte Count, Malaria/immunology, Male, Plasmodium vivax, Splenectomy
Identifiers
Local EPrints ID: 468580
URI: http://eprints.soton.ac.uk/id/eprint/468580
ISSN: 0031-1820
PURE UUID: b0a9a28d-0d39-4b82-9874-cc914ad2653d
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Date deposited: 18 Aug 2022 16:40
Last modified: 17 Mar 2024 03:11
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Author:
G H Mitchell
Author:
D A Johnston
Author:
B A Naylor
Author:
A M Knight
Author:
N Wedderburn
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