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Genetic epidemiology of complex phenotypes

Genetic epidemiology of complex phenotypes
Genetic epidemiology of complex phenotypes
A theory is given for complex phenotypes represented by an ordered polychotomy separately for affected (as severity) and for normals (as diathesis), with consideration of history, ascertainment, sampling frames, and phenotype systems. Nonrandom selection of probands by severity is permitted. Both probit and logistic models are developed in a form compatible with segregation and/or linkage analysis. Probabilities are set out in detail in the Appendix. This approach avoids problems that have been encountered with quantitative traits and correlated phenotypes, although using this information.
0003-4800
301-314
Collins, Andrew
7daa83eb-0b21-43b2-af1a-e38fb36e2a64
Collins, Andrew
7daa83eb-0b21-43b2-af1a-e38fb36e2a64

Collins, Andrew (1991) Genetic epidemiology of complex phenotypes. Annals of Human Genetics, 55 (4), 301-314.

Record type: Article

Abstract

A theory is given for complex phenotypes represented by an ordered polychotomy separately for affected (as severity) and for normals (as diathesis), with consideration of history, ascertainment, sampling frames, and phenotype systems. Nonrandom selection of probands by severity is permitted. Both probit and logistic models are developed in a form compatible with segregation and/or linkage analysis. Probabilities are set out in detail in the Appendix. This approach avoids problems that have been encountered with quantitative traits and correlated phenotypes, although using this information.

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More information

Published date: 1 October 1991
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Identifiers

Local EPrints ID: 468605
URI: http://eprints.soton.ac.uk/id/eprint/468605
ISSN: 0003-4800
PURE UUID: 10404843-1f96-44b1-af14-20346bdc0a2b
ORCID for Andrew Collins: ORCID iD orcid.org/0000-0001-7108-0771

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Date deposited: 18 Aug 2022 16:42
Last modified: 19 Aug 2022 01:32

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Author: Andrew Collins ORCID iD

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