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AI3SD Video: Translating innovations out of the lab and into the clinic: the importance of data curation, AI and ML?

AI3SD Video: Translating innovations out of the lab and into the clinic: the importance of data curation, AI and ML?
AI3SD Video: Translating innovations out of the lab and into the clinic: the importance of data curation, AI and ML?
Our novel patented (European Patent Application No. 18743767.8, U.S. Patent Application No. 16/632,194), Supramolecular Self-associating Amphiphile (SSA) platform technology currently contains a library of ≈ 120 molecules (Figure 1), invented by J. Hiscock in 2016, has since been developed by an international, transdisciplinary team of ≈50 academic/industrial/governmental scientists, social scientists and clinicians. To date this molecular technology has been shown to:

1.act as broad-spectrum antimicrobials;1–6
2. increase the efficacy of other antibiotic/antiseptic agents and anticancer agents against bacteria7 and ovarian cancer cells respectively;8
3. selectively interact with phospholipid membranes of different compositions;9,10
4. have the potential to act as drug delivery vehicles;11
5. exhibits a drugable profile when administered by i.v. in vivo (unpublished data);
6. and enable the production of novel flow battery electrolytes.12

However, this means the we not only create a lot of data, but that these multiple outputs exist in multiple forms, come from all over the world and are underutilised when designing the next project steps. Here we will attempt to introduce you to our approach in solving these problems.

References

(1) Chem. Commun., 2021, 57, 11839 – 11842; (2) Supramol. Chem., 2020, 32, 414–424; (3) J. Mater. Chem. B, 2020, 8, 4694–4700; (4) ChemMedChem, 2020, 15, 2193–2205; (5) Supramol. Chem., 2020, 32, 414–424; (6) Chem. Commun., 2019, 55, 95–98; (7) RSC Advances, 2021, 11, 9550 – 9556; (8) RSC Advances, 2021, 11, 14213 - 14217; (9) Chem. Commun., 2020, 56, 4015–4018; (10) Chem. Commun., 2020, 56, 11665–11668; (11) Molecules, 2020 , 25:18, 4126-4141; (12) Chem. Commun., 2020, 56, 11815-11818.
Hiscock, Jennifer R.
54da213c-badc-4ddb-b23c-9561367b2f90
Allam, Thomas
da20864d-b1ec-4065-95c3-ec3ed62286e2
Frey, Jeremy G.
ba60c559-c4af-44f1-87e6-ce69819bf23f
Niranjan, Mahesan
5cbaeea8-7288-4b55-a89c-c43d212ddd4f
Hiscock, Jennifer R.
54da213c-badc-4ddb-b23c-9561367b2f90
Allam, Thomas
da20864d-b1ec-4065-95c3-ec3ed62286e2
Frey, Jeremy G.
ba60c559-c4af-44f1-87e6-ce69819bf23f
Niranjan, Mahesan
5cbaeea8-7288-4b55-a89c-c43d212ddd4f

Hiscock, Jennifer R. and Allam, Thomas (2022) AI3SD Video: Translating innovations out of the lab and into the clinic: the importance of data curation, AI and ML? Frey, Jeremy G. and Niranjan, Mahesan (eds.) AI4SD Network+ Conference, Chilworth Manor , Southampton, United Kingdom. 01 - 03 Mar 2022. (doi:10.5258/SOTON/AI3SD0188).

Record type: Conference or Workshop Item (Other)

Abstract

Our novel patented (European Patent Application No. 18743767.8, U.S. Patent Application No. 16/632,194), Supramolecular Self-associating Amphiphile (SSA) platform technology currently contains a library of ≈ 120 molecules (Figure 1), invented by J. Hiscock in 2016, has since been developed by an international, transdisciplinary team of ≈50 academic/industrial/governmental scientists, social scientists and clinicians. To date this molecular technology has been shown to:

1.act as broad-spectrum antimicrobials;1–6
2. increase the efficacy of other antibiotic/antiseptic agents and anticancer agents against bacteria7 and ovarian cancer cells respectively;8
3. selectively interact with phospholipid membranes of different compositions;9,10
4. have the potential to act as drug delivery vehicles;11
5. exhibits a drugable profile when administered by i.v. in vivo (unpublished data);
6. and enable the production of novel flow battery electrolytes.12

However, this means the we not only create a lot of data, but that these multiple outputs exist in multiple forms, come from all over the world and are underutilised when designing the next project steps. Here we will attempt to introduce you to our approach in solving these problems.

References

(1) Chem. Commun., 2021, 57, 11839 – 11842; (2) Supramol. Chem., 2020, 32, 414–424; (3) J. Mater. Chem. B, 2020, 8, 4694–4700; (4) ChemMedChem, 2020, 15, 2193–2205; (5) Supramol. Chem., 2020, 32, 414–424; (6) Chem. Commun., 2019, 55, 95–98; (7) RSC Advances, 2021, 11, 9550 – 9556; (8) RSC Advances, 2021, 11, 14213 - 14217; (9) Chem. Commun., 2020, 56, 4015–4018; (10) Chem. Commun., 2020, 56, 11665–11668; (11) Molecules, 2020 , 25:18, 4126-4141; (12) Chem. Commun., 2020, 56, 11815-11818.

Video
ai4sd_march_2022_day_1_JenHTomA - Version of Record
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More information

Published date: 1 March 2022
Additional Information: Dr Jennifer Hiscock obtained her PhD from the University of Southampton (UK) under the supervision of Prof. Philip A. Gale in 2010 studying supramolecular host:guest chemistry. She continued her post-doctoral research between this group and Dstl (Porton Down – UK) until 2015 when she moved to the University of Kent (UK) as the Caldin research fellow. In 2016 she was awarded a permanent lectureship position at that same institution, which has since been followed by her promotion to Reader in Supramolecular Chemistry and Director of Innovation and Enterprise for the School of Physical Sciences in 2019. In 2020 she was awarded a UKRI Future Leaders Fellowship, developing novel cell surface active therapeutics and drug adjuvants and in 2021 her efforts were recognised through the award of the consolidator prize for research by the University of Kent. Her research currently focuses on a transdisciplinary approach to applying supramolecular chemistry to solve real-world problems.
Venue - Dates: AI4SD Network+ Conference, Chilworth Manor , Southampton, United Kingdom, 2022-03-01 - 2022-03-03
Related URLs:
Learn more about School of Chemistry research Learn more about Vision, Learning and Control research Learn more about Institute for Life Sciences research

Identifiers

Local EPrints ID: 468628
URI: http://eprints.soton.ac.uk/id/eprint/468628
DOI: doi:10.5258/SOTON/AI3SD0188
PURE UUID: 13c03a58-f39f-41e2-a0e9-82dc291a92a5
ORCID for Jeremy G. Frey: ORCID iD orcid.org/0000-0003-0842-4302
ORCID for Mahesan Niranjan: ORCID iD orcid.org/0000-0001-7021-140X

Catalogue record

Date deposited: 19 Aug 2022 16:32
Last modified: 17 Mar 2024 03:11

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Contributors

Author: Jennifer R. Hiscock
Author: Thomas Allam
Editor: Jeremy G. Frey ORCID iD
Editor: Mahesan Niranjan ORCID iD

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