Association of upper airway bacterial microbiota and asthma: systematic review
Association of upper airway bacterial microbiota and asthma: systematic review
Individual studies have suggested that upper airway dysbiosis may be associated with asthma or its severity. We aimed to systematically review studies that evaluated upper airway bacterial microbiota in relation to asthma, compared to nonasthmatic controls. Searches used MEDLINE, Embase, and Web of Science Core Collection. Eligible studies included association between asthma and upper airway dysbiosis; assessment of composition and diversity of upper airway microbiota using 16S rRNA or metagenomic sequencing; upper airway samples from nose, nasopharynx, oropharynx or hypopharynx. Study quality was assessed and rated using the Newcastle-Ottawa scale. A total of 249 publications were identified; 17 in the final analysis (13 childhood asthma and 4 adult asthma). Microbiome richness was measured in 6 studies, species diversity in 12, and bacterial composition in 17. The quality of evidence was good and fair. The alpha-diversity was found to be higher in younger children with wheezing and asthma, while it was lower when asthmatic children had rhinitis or mite sensitization. In children, Proteobacteria and Firmicutes were higher in asthmatics compared to controls (7 studies), and Moraxella, Streptococcus, and Haemophilus were predominant in the bacterial community. In pooled analysis, nasal Streptococcus colonization was associated with the presence of wheezing at age 5 (p = 0.04). In adult patients with asthma, the abundance of Proteobacteria was elevated in the upper respiratory tract (3 studies). Nasal colonization of Corynebacterium was lower in asthmatics (2 studies). This study demonstrates the potential relationships between asthma and specific bacterial colonization in the upper airway in adult and children with asthma.
Losol, Purevsuren
13912f45-98d6-4aba-b057-0027993de4c7
Park, Hee-Sun
c0377293-0ddb-4b33-976d-f748003ab283
Song, Woo-Jung
82991af5-ab6a-4b7a-a111-027d3c7808f1
Hwang, Yu-Kyoung
33f11c25-757e-49e7-b19b-49010bfc3e8b
Kim, Sae-Hoon
81a4a809-ddb7-4291-897f-62f5177a49ac
Holloway, John W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Chang, Yoon-Seok
6c517880-794d-4b83-926d-1940310e2ce5
29 July 2022
Losol, Purevsuren
13912f45-98d6-4aba-b057-0027993de4c7
Park, Hee-Sun
c0377293-0ddb-4b33-976d-f748003ab283
Song, Woo-Jung
82991af5-ab6a-4b7a-a111-027d3c7808f1
Hwang, Yu-Kyoung
33f11c25-757e-49e7-b19b-49010bfc3e8b
Kim, Sae-Hoon
81a4a809-ddb7-4291-897f-62f5177a49ac
Holloway, John W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Chang, Yoon-Seok
6c517880-794d-4b83-926d-1940310e2ce5
Losol, Purevsuren, Park, Hee-Sun, Song, Woo-Jung, Hwang, Yu-Kyoung, Kim, Sae-Hoon, Holloway, John W. and Chang, Yoon-Seok
(2022)
Association of upper airway bacterial microbiota and asthma: systematic review.
Asia Pacific Allergy, 12 (3), [e32].
(doi:10.5415/apallergy.2022.12.e32).
Abstract
Individual studies have suggested that upper airway dysbiosis may be associated with asthma or its severity. We aimed to systematically review studies that evaluated upper airway bacterial microbiota in relation to asthma, compared to nonasthmatic controls. Searches used MEDLINE, Embase, and Web of Science Core Collection. Eligible studies included association between asthma and upper airway dysbiosis; assessment of composition and diversity of upper airway microbiota using 16S rRNA or metagenomic sequencing; upper airway samples from nose, nasopharynx, oropharynx or hypopharynx. Study quality was assessed and rated using the Newcastle-Ottawa scale. A total of 249 publications were identified; 17 in the final analysis (13 childhood asthma and 4 adult asthma). Microbiome richness was measured in 6 studies, species diversity in 12, and bacterial composition in 17. The quality of evidence was good and fair. The alpha-diversity was found to be higher in younger children with wheezing and asthma, while it was lower when asthmatic children had rhinitis or mite sensitization. In children, Proteobacteria and Firmicutes were higher in asthmatics compared to controls (7 studies), and Moraxella, Streptococcus, and Haemophilus were predominant in the bacterial community. In pooled analysis, nasal Streptococcus colonization was associated with the presence of wheezing at age 5 (p = 0.04). In adult patients with asthma, the abundance of Proteobacteria was elevated in the upper respiratory tract (3 studies). Nasal colonization of Corynebacterium was lower in asthmatics (2 studies). This study demonstrates the potential relationships between asthma and specific bacterial colonization in the upper airway in adult and children with asthma.
Text
9996APA_apa-12-e32
- Version of Record
More information
Accepted/In Press date: 28 July 2022
e-pub ahead of print date: 29 July 2022
Published date: 29 July 2022
Identifiers
Local EPrints ID: 468743
URI: http://eprints.soton.ac.uk/id/eprint/468743
ISSN: 2233-8276
PURE UUID: b61bf60e-3bc1-45c7-8be5-30b7595c04f9
Catalogue record
Date deposited: 24 Aug 2022 16:38
Last modified: 03 Dec 2025 03:08
Export record
Altmetrics
Contributors
Author:
Purevsuren Losol
Author:
Hee-Sun Park
Author:
Woo-Jung Song
Author:
Yu-Kyoung Hwang
Author:
Sae-Hoon Kim
Author:
Yoon-Seok Chang
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics