Linking nutrition to long-term health: Epigenetic mechanisms
Linking nutrition to long-term health: Epigenetic mechanisms
Nutritional intake during key developmental windows in early life has increasingly been linked to long-term health trajectories and the risk of non-communicable disease. The mechanisms by which early-life environment can influence later phenotypes and long-term disease risk has been suggested to include epigenetic processes. Epigenetic processes modulate gene expression without a change in the DNA nucleotide sequence, determining when and where a gene is expressed. Both maternal and paternal diet have been shown to induce epigenetic changes in the offspring, leading to changes in gene expression that can persist throughout the life course and influence later disease susceptibility. This has led in recent years to the identification of epigenetic markers for lifestyle-related disease risk being investigated as potential therapeutic biomarkers. Elucidation of such modifiable epigenetic processes linked to non-communicable disease risk may enable early intervention strategies using targeted approaches through nutrition or pharmacological epigenetic modifiers to improve long-term health.
Biomarkers, Environment, Epigenetics, Health, Intervention, Methylation, Nutrition
257 - 277
Burton, Mark
250319ad-90dc-4651-b118-d5dbe5eaafa6
Godfrey, Keith
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Lillycrop, Karen
eeaaa78d-0c4d-4033-a178-60ce7345a2cc
August 2022
Burton, Mark
250319ad-90dc-4651-b118-d5dbe5eaafa6
Godfrey, Keith
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Lillycrop, Karen
eeaaa78d-0c4d-4033-a178-60ce7345a2cc
Burton, Mark, Godfrey, Keith and Lillycrop, Karen
(2022)
Linking nutrition to long-term health: Epigenetic mechanisms.
In,
Saavedra, Jose M. and Dattilo, Anne M.
(eds.)
Early Nutrition and Long-Term Health: Mechanisms, Consequences, and Opportunities, Second Edition.
Second ed.
Woodhead Publishing, .
(doi:10.1016/b978-0-12-824389-3.00017-9).
Record type:
Book Section
Abstract
Nutritional intake during key developmental windows in early life has increasingly been linked to long-term health trajectories and the risk of non-communicable disease. The mechanisms by which early-life environment can influence later phenotypes and long-term disease risk has been suggested to include epigenetic processes. Epigenetic processes modulate gene expression without a change in the DNA nucleotide sequence, determining when and where a gene is expressed. Both maternal and paternal diet have been shown to induce epigenetic changes in the offspring, leading to changes in gene expression that can persist throughout the life course and influence later disease susceptibility. This has led in recent years to the identification of epigenetic markers for lifestyle-related disease risk being investigated as potential therapeutic biomarkers. Elucidation of such modifiable epigenetic processes linked to non-communicable disease risk may enable early intervention strategies using targeted approaches through nutrition or pharmacological epigenetic modifiers to improve long-term health.
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Published date: August 2022
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Publisher Copyright:
© 2022 Elsevier Ltd. All rights reserved.
Keywords:
Biomarkers, Environment, Epigenetics, Health, Intervention, Methylation, Nutrition
Identifiers
Local EPrints ID: 468816
URI: http://eprints.soton.ac.uk/id/eprint/468816
PURE UUID: d0ca4745-e253-4446-9ea4-4f639c589ba4
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Date deposited: 26 Aug 2022 16:40
Last modified: 09 Jul 2024 01:53
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Contributors
Editor:
Jose M. Saavedra
Editor:
Anne M. Dattilo
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