The University of Southampton
University of Southampton Institutional Repository

Linking nutrition to long-term health: Epigenetic mechanisms

Linking nutrition to long-term health: Epigenetic mechanisms
Linking nutrition to long-term health: Epigenetic mechanisms
Nutritional intake during key developmental windows in early life has increasingly been linked to long-term health trajectories and the risk of non-communicable disease. The mechanisms by which early-life environment can influence later phenotypes and long-term disease risk has been suggested to include epigenetic processes. Epigenetic processes modulate gene expression without a change in the DNA nucleotide sequence, determining when and where a gene is expressed. Both maternal and paternal diet have been shown to induce epigenetic changes in the offspring, leading to changes in gene expression that can persist throughout the life course and influence later disease susceptibility. This has led in recent years to the identification of epigenetic markers for lifestyle-related disease risk being investigated as potential therapeutic biomarkers. Elucidation of such modifiable epigenetic processes linked to non-communicable disease risk may enable early intervention strategies using targeted approaches through nutrition or pharmacological epigenetic modifiers to improve long-term health.
Biomarkers, Environment, Epigenetics, Health, Intervention, Methylation, Nutrition
257 - 277
Woodhead Publishing
Burton, Mark
250319ad-90dc-4651-b118-d5dbe5eaafa6
Godfrey, Keith
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Lillycrop, Karen
eeaaa78d-0c4d-4033-a178-60ce7345a2cc
Saavedra, Jose M.
Dattilo, Anne M.
Burton, Mark
250319ad-90dc-4651-b118-d5dbe5eaafa6
Godfrey, Keith
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Lillycrop, Karen
eeaaa78d-0c4d-4033-a178-60ce7345a2cc
Saavedra, Jose M.
Dattilo, Anne M.

Burton, Mark, Godfrey, Keith and Lillycrop, Karen (2022) Linking nutrition to long-term health: Epigenetic mechanisms. In, Saavedra, Jose M. and Dattilo, Anne M. (eds.) Early Nutrition and Long-Term Health: Mechanisms, Consequences, and Opportunities, Second Edition. Second ed. Woodhead Publishing, 257 - 277. (doi:10.1016/b978-0-12-824389-3.00017-9).

Record type: Book Section

Abstract

Nutritional intake during key developmental windows in early life has increasingly been linked to long-term health trajectories and the risk of non-communicable disease. The mechanisms by which early-life environment can influence later phenotypes and long-term disease risk has been suggested to include epigenetic processes. Epigenetic processes modulate gene expression without a change in the DNA nucleotide sequence, determining when and where a gene is expressed. Both maternal and paternal diet have been shown to induce epigenetic changes in the offspring, leading to changes in gene expression that can persist throughout the life course and influence later disease susceptibility. This has led in recent years to the identification of epigenetic markers for lifestyle-related disease risk being investigated as potential therapeutic biomarkers. Elucidation of such modifiable epigenetic processes linked to non-communicable disease risk may enable early intervention strategies using targeted approaches through nutrition or pharmacological epigenetic modifiers to improve long-term health.

This record has no associated files available for download.

More information

Published date: August 2022
Additional Information: Publisher Copyright: © 2022 Elsevier Ltd. All rights reserved.
Keywords: Biomarkers, Environment, Epigenetics, Health, Intervention, Methylation, Nutrition

Identifiers

Local EPrints ID: 468816
URI: http://eprints.soton.ac.uk/id/eprint/468816
PURE UUID: d0ca4745-e253-4446-9ea4-4f639c589ba4
ORCID for Mark Burton: ORCID iD orcid.org/0000-0002-7117-8151
ORCID for Keith Godfrey: ORCID iD orcid.org/0000-0002-4643-0618
ORCID for Karen Lillycrop: ORCID iD orcid.org/0000-0001-7350-5489

Catalogue record

Date deposited: 26 Aug 2022 16:40
Last modified: 09 Jul 2024 01:53

Export record

Altmetrics

Contributors

Author: Mark Burton ORCID iD
Author: Keith Godfrey ORCID iD
Author: Karen Lillycrop ORCID iD
Editor: Jose M. Saavedra
Editor: Anne M. Dattilo

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×