Efficacy on sleep parameters and tolerability of melatonin in individuals with sleep or mental disorders: A systematic review and meta-analysis
Efficacy on sleep parameters and tolerability of melatonin in individuals with sleep or mental disorders: A systematic review and meta-analysis
We conducted the first systematic review and series of meta-analyses to assess the efficacy and tolerability of melatonin in children/adolescents or adults with sleep or mental health disorders, using the same set of criteria across disorders and ages. Based on a pre-registered protocol (PROPSPERO: CRD42021289827), we searched a broad range of electronic databases up to 02.02.2021 for randomized control trials (RCTs) of melatonin. We assessed study quality using the Risk of Bias tool, v2. We included a total of 34 RCTs (21 in children/adolescents: N = 984; 13 in adults: N = 1014). We found evidence that melatonin significantly improved sleep onset latency and total sleep time, but not sleep awaking, in children and adolescents with a variety of neurodevelopmental disorders, and sleep onset latency (measured by diary) as well as total sleep time (measured with polysomnography) in adults with delayed sleep phase disorder. No evidence of significant differences between melatonin and placebo was found in terms of tolerability. We discuss clinical and research implications of our findings.
ADHD, ASD, Melatonin, Neurodevelopmental, Sleep
104723
Salanitro, Matthew
df11cd91-6f3f-4c13-a838-84f301009c77
Wrigley, Torsten
be315bab-eb97-485e-a781-c139eb9a8087
Ghabra, Hisham
e57485c6-0a85-4575-96a9-451c46e1e148
de Haan, Edward
36576be6-7760-4e78-81b3-814fc88855d0
Hill, Catherine M
172dc851-574e-4815-9c5e-4de4dae9fc35
Solmi, Marco
2022a2e4-774d-4811-b1db-b6dbfedbd10d
Cortese, Samuele
53d4bf2c-4e0e-4c77-9385-218350560fdb
August 2022
Salanitro, Matthew
df11cd91-6f3f-4c13-a838-84f301009c77
Wrigley, Torsten
be315bab-eb97-485e-a781-c139eb9a8087
Ghabra, Hisham
e57485c6-0a85-4575-96a9-451c46e1e148
de Haan, Edward
36576be6-7760-4e78-81b3-814fc88855d0
Hill, Catherine M
172dc851-574e-4815-9c5e-4de4dae9fc35
Solmi, Marco
2022a2e4-774d-4811-b1db-b6dbfedbd10d
Cortese, Samuele
53d4bf2c-4e0e-4c77-9385-218350560fdb
Salanitro, Matthew, Wrigley, Torsten, Ghabra, Hisham, de Haan, Edward, Hill, Catherine M, Solmi, Marco and Cortese, Samuele
(2022)
Efficacy on sleep parameters and tolerability of melatonin in individuals with sleep or mental disorders: A systematic review and meta-analysis.
Neuroscience and Biobehavioral Reviews, 139, , [104723].
(doi:10.1016/j.neubiorev.2022.104723).
Abstract
We conducted the first systematic review and series of meta-analyses to assess the efficacy and tolerability of melatonin in children/adolescents or adults with sleep or mental health disorders, using the same set of criteria across disorders and ages. Based on a pre-registered protocol (PROPSPERO: CRD42021289827), we searched a broad range of electronic databases up to 02.02.2021 for randomized control trials (RCTs) of melatonin. We assessed study quality using the Risk of Bias tool, v2. We included a total of 34 RCTs (21 in children/adolescents: N = 984; 13 in adults: N = 1014). We found evidence that melatonin significantly improved sleep onset latency and total sleep time, but not sleep awaking, in children and adolescents with a variety of neurodevelopmental disorders, and sleep onset latency (measured by diary) as well as total sleep time (measured with polysomnography) in adults with delayed sleep phase disorder. No evidence of significant differences between melatonin and placebo was found in terms of tolerability. We discuss clinical and research implications of our findings.
Text
1-s2.0-S0149763422002123-main
- Version of Record
More information
Accepted/In Press date: 1 June 2022
e-pub ahead of print date: 9 June 2022
Published date: August 2022
Additional Information:
Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.
Keywords:
ADHD, ASD, Melatonin, Neurodevelopmental, Sleep
Identifiers
Local EPrints ID: 468887
URI: http://eprints.soton.ac.uk/id/eprint/468887
ISSN: 0149-7634
PURE UUID: 14cbb72f-db12-4d07-a68b-d3fe7c32a3ad
Catalogue record
Date deposited: 31 Aug 2022 16:53
Last modified: 17 Mar 2024 03:37
Export record
Altmetrics
Contributors
Author:
Matthew Salanitro
Author:
Torsten Wrigley
Author:
Hisham Ghabra
Author:
Edward de Haan
Author:
Catherine M Hill
Author:
Marco Solmi
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
