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Counting algorithms for linkage

Counting algorithms for linkage
Counting algorithms for linkage
The Lander-Green algorithm is algebraically different from the EM algorithm that maximizes likelihood. In our experience the numerical difference is very small. Since computations are no easier or convergence faster for the Lander–Green algorithm, there is no reason to prefer it to EM. As suggested by Green (personal communication), layering is advantageous. Occasional updating of the information weights might also be considered to accelerate mapping.
0003-4800
103-106
Morton, NE
c668e2be-074a-4a0a-a2ca-e8f51830ebb7
Collins, A
7daa83eb-0b21-43b2-af1a-e38fb36e2a64
Morton, NE
c668e2be-074a-4a0a-a2ca-e8f51830ebb7
Collins, A
7daa83eb-0b21-43b2-af1a-e38fb36e2a64

Morton, NE and Collins, A (1990) Counting algorithms for linkage. Annals of Human Genetics, 54 (2), 103-106. (doi:10.1111/j.1469-1809.1990.tb00365.x).

Record type: Article

Abstract

The Lander-Green algorithm is algebraically different from the EM algorithm that maximizes likelihood. In our experience the numerical difference is very small. Since computations are no easier or convergence faster for the Lander–Green algorithm, there is no reason to prefer it to EM. As suggested by Green (personal communication), layering is advantageous. Occasional updating of the information weights might also be considered to accelerate mapping.

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Published date: 1 January 1990
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Identifiers

Local EPrints ID: 469002
URI: http://eprints.soton.ac.uk/id/eprint/469002
DOI: doi:10.1111/j.1469-1809.1990.tb00365.x
ISSN: 0003-4800
PURE UUID: 72b0ee94-17fe-4f92-b5b4-45fec6c0eced
ORCID for A Collins: ORCID iD orcid.org/0000-0001-7108-0771

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Date deposited: 05 Sep 2022 16:36
Last modified: 17 Mar 2024 02:37

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Author: NE Morton
Author: A Collins ORCID iD

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