Genomics and the biology of parasites
Genomics and the biology of parasites
Despite the advances of modern medicine, the threat of chronic illness, disfigurement, or death that can result from parasitic infection still affects the majority of the world population, retarding economic development. For most parasitic diseases, current therapeutics often leave much to be desired in terms of administration regime, toxicity, or effectiveness and potential vaccines are a long way from market. Our best prospects for identifying new targets for drug, vaccine, and diagnostics development and for dissecting the biological basis of drug resistance, antigenic diversity, infectivity and pathology lie in parasite genome analysis, and international mapping and gene discovery initiatives are under way for a variety of protozoan and helminth parasites. These are far from ideal experimental organisms, and the influence of biological and genomic characteristics on experimental approaches is discussed, progress is reviewed and future prospects are examined.
Animals, Databases, Factual, Eukaryota/genetics, Genome, Helminths/genetics, Humans, Parasites/genetics, Physical Chromosome Mapping, Research Design
131-47
Johnston, D A
b41163c9-b9d2-425c-af99-2a357204014e
Blaxter, M L
5f03450c-455a-448d-97cc-ea096ba0c57e
Degrave, W M
56b95dcd-fae5-4516-8ee3-e464c3f6ed72
Foster, J
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Ivens, A C
f6b6c828-bd07-412f-9c07-f076a2f6ebd1
Melville, S E
07abb72b-0739-421f-9fa7-1b39acc6e139
February 1999
Johnston, D A
b41163c9-b9d2-425c-af99-2a357204014e
Blaxter, M L
5f03450c-455a-448d-97cc-ea096ba0c57e
Degrave, W M
56b95dcd-fae5-4516-8ee3-e464c3f6ed72
Foster, J
0772dd54-3520-4700-a649-1c7195428550
Ivens, A C
f6b6c828-bd07-412f-9c07-f076a2f6ebd1
Melville, S E
07abb72b-0739-421f-9fa7-1b39acc6e139
Johnston, D A, Blaxter, M L, Degrave, W M, Foster, J, Ivens, A C and Melville, S E
(1999)
Genomics and the biology of parasites.
BioEssays, 21 (2), .
(doi:10.1002/(SICI)1521-1878(199902)21:2<131::AID-BIES7>3.0.CO;2-I).
Abstract
Despite the advances of modern medicine, the threat of chronic illness, disfigurement, or death that can result from parasitic infection still affects the majority of the world population, retarding economic development. For most parasitic diseases, current therapeutics often leave much to be desired in terms of administration regime, toxicity, or effectiveness and potential vaccines are a long way from market. Our best prospects for identifying new targets for drug, vaccine, and diagnostics development and for dissecting the biological basis of drug resistance, antigenic diversity, infectivity and pathology lie in parasite genome analysis, and international mapping and gene discovery initiatives are under way for a variety of protozoan and helminth parasites. These are far from ideal experimental organisms, and the influence of biological and genomic characteristics on experimental approaches is discussed, progress is reviewed and future prospects are examined.
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Published date: February 1999
Keywords:
Animals, Databases, Factual, Eukaryota/genetics, Genome, Helminths/genetics, Humans, Parasites/genetics, Physical Chromosome Mapping, Research Design
Identifiers
Local EPrints ID: 469210
URI: http://eprints.soton.ac.uk/id/eprint/469210
ISSN: 0265-9247
PURE UUID: f0ed229c-f02a-4142-aa9e-1171fc9d7ac9
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Date deposited: 09 Sep 2022 16:37
Last modified: 17 Mar 2024 03:11
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Author:
D A Johnston
Author:
M L Blaxter
Author:
W M Degrave
Author:
J Foster
Author:
A C Ivens
Author:
S E Melville
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