Regulation of insulin gene expression by the IDDM associated, insulin locus haplotype
Regulation of insulin gene expression by the IDDM associated, insulin locus haplotype
A 4.1 kb genomic region, spanning the insulin (INS) gene, confers genetic susceptibility to Type 1 or insulin-dependent diabetes mellitus (IDDM). Ten polymorphisms within this region form two predominant, complementary haplotypes. We have been studying the effects of these polymorphisms on the levels of insulin mRNA. Cloned genomic DNA fragments representing these two separate haplotypes were transiently transfected into a rodent pancreatic β cell line, HIT-T15. These studies revealed that insulin mRNA levels were consistently higher in the transfectants expressing the diabetic haplotype. Over-expression of insulin mRNA may provide the basic mechanism for the diabetic susceptibility encoded at the INS locus. / 1995 Oxford University Press.
501-506
Lucassen, Anneke M.
2eb85efc-c6e8-4c3f-b963-0290f6c038a5
Screaton, Gavin R.
5f3f34e7-588d-4352-9e56-62e32fa10611
Julier, Cecile
1f5504f1-dba7-409d-a658-c444776757fa
Elliott, Tim J.
16670fa8-c2f9-477a-91df-7c9e5b453e0e
Lathrop, Mark
ff1cfeeb-96fe-49dc-980f-595ce2f390fb
Bell, John I.
d56c17b1-e293-4c12-9545-25187f8ef9a1
1 April 1995
Lucassen, Anneke M.
2eb85efc-c6e8-4c3f-b963-0290f6c038a5
Screaton, Gavin R.
5f3f34e7-588d-4352-9e56-62e32fa10611
Julier, Cecile
1f5504f1-dba7-409d-a658-c444776757fa
Elliott, Tim J.
16670fa8-c2f9-477a-91df-7c9e5b453e0e
Lathrop, Mark
ff1cfeeb-96fe-49dc-980f-595ce2f390fb
Bell, John I.
d56c17b1-e293-4c12-9545-25187f8ef9a1
Lucassen, Anneke M., Screaton, Gavin R., Julier, Cecile, Elliott, Tim J., Lathrop, Mark and Bell, John I.
(1995)
Regulation of insulin gene expression by the IDDM associated, insulin locus haplotype.
Human Molecular Genetics, 4 (4), .
(doi:10.1093/hmg/4.4.501).
Abstract
A 4.1 kb genomic region, spanning the insulin (INS) gene, confers genetic susceptibility to Type 1 or insulin-dependent diabetes mellitus (IDDM). Ten polymorphisms within this region form two predominant, complementary haplotypes. We have been studying the effects of these polymorphisms on the levels of insulin mRNA. Cloned genomic DNA fragments representing these two separate haplotypes were transiently transfected into a rodent pancreatic β cell line, HIT-T15. These studies revealed that insulin mRNA levels were consistently higher in the transfectants expressing the diabetic haplotype. Over-expression of insulin mRNA may provide the basic mechanism for the diabetic susceptibility encoded at the INS locus. / 1995 Oxford University Press.
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Published date: 1 April 1995
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Local EPrints ID: 469451
URI: http://eprints.soton.ac.uk/id/eprint/469451
ISSN: 0964-6906
PURE UUID: f45c805c-8c9e-4533-b15f-411a24fd252f
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Date deposited: 14 Sep 2022 16:52
Last modified: 17 Mar 2024 02:54
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Contributors
Author:
Gavin R. Screaton
Author:
Cecile Julier
Author:
Mark Lathrop
Author:
John I. Bell
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