Dietary acrylamide and incident osteoporotic fractures: an 8-year prospective cohort study
Dietary acrylamide and incident osteoporotic fractures: an 8-year prospective cohort study
Background: acrylamide, a component of fried foods, has been associated with several negative health outcomes. However, the relationship between dietary acrylamide and osteoporotic fractures has been explored by a few cross-sectional studies.
Aims: to investigate if dietary acrylamide is associated with the onset of fractures in North American participants at high risk/having knee osteoarthritis (OA), over 8 years of follow-up.
Methods: a Cox’s regression analysis, adjusted for baseline confounders was run and the data were reported as hazard ratios (HRs) and 95% confidence intervals (CIs). Dietary acrylamide intake was assessed at the baseline using a food frequency questionnaire and categorized in tertiles (T), whilst fractures’ history was recorded using self-reported information.
Results: altogether, 4,436 participants were included. Compared to participants with lower acrylamide intake (T1; < 3,313 μg), those with a higher acrylamide intake (T3; > 10,180 μg) reported a significantly higher risk of any fracture (HR = 1.37; 95% CI 1.12–1.68; p for trend = 0.009), forearm (HR = 1.73; 95% CI 1.09–2.77; p for trend = 0.04), spine (HR = 2.21; 95% CI 1.14–4.31; p for trend = 0.04), and hip fracture (HR = 4.09; 95% CI 1.29–12.96; p for trend = 0.046).
Conclusions: our study is the first to report that high dietary acrylamide may be associated with an increased risk of osteoporotic fractures.
Acrylamide, Fracture, Osteoarthritis initiative, Osteoporosis
2441-2448
Veronese, Nicola
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Bolzetta, Francesco
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Cacco, Chiara
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Cester, Alberto
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Smith, Lee
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Demurtas, Jacopo
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Cooper, Cyrus
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Rizzoli, Rene
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Caruso, Maria Gabriella
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Notanicola, Maria
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Reginster, Jean-Yves
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Maggi, Stefania
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Barbagallo, Mario
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Trott, Mike
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Dominguez, Ligia J.
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October 2022
Veronese, Nicola
a9a97f63-a828-45a3-bae0-68182c5a44fd
Bolzetta, Francesco
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Cacco, Chiara
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Cester, Alberto
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Smith, Lee
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Demurtas, Jacopo
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Cooper, Cyrus
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Rizzoli, Rene
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Caruso, Maria Gabriella
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Notanicola, Maria
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Reginster, Jean-Yves
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Maggi, Stefania
57e7e62a-b7dd-4291-82e3-efc8c9a7e12a
Barbagallo, Mario
253443e1-cdf1-4549-ac04-c18c27d11d1a
Trott, Mike
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Dominguez, Ligia J.
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Veronese, Nicola, Bolzetta, Francesco, Cacco, Chiara, Cester, Alberto, Smith, Lee, Demurtas, Jacopo, Cooper, Cyrus, Rizzoli, Rene, Caruso, Maria Gabriella, Notanicola, Maria, Reginster, Jean-Yves, Maggi, Stefania, Barbagallo, Mario, Trott, Mike and Dominguez, Ligia J.
(2022)
Dietary acrylamide and incident osteoporotic fractures: an 8-year prospective cohort study.
Aging Clinical and Experimental Research, 34 (10), .
(doi:10.1007/s40520-022-02214-9).
Abstract
Background: acrylamide, a component of fried foods, has been associated with several negative health outcomes. However, the relationship between dietary acrylamide and osteoporotic fractures has been explored by a few cross-sectional studies.
Aims: to investigate if dietary acrylamide is associated with the onset of fractures in North American participants at high risk/having knee osteoarthritis (OA), over 8 years of follow-up.
Methods: a Cox’s regression analysis, adjusted for baseline confounders was run and the data were reported as hazard ratios (HRs) and 95% confidence intervals (CIs). Dietary acrylamide intake was assessed at the baseline using a food frequency questionnaire and categorized in tertiles (T), whilst fractures’ history was recorded using self-reported information.
Results: altogether, 4,436 participants were included. Compared to participants with lower acrylamide intake (T1; < 3,313 μg), those with a higher acrylamide intake (T3; > 10,180 μg) reported a significantly higher risk of any fracture (HR = 1.37; 95% CI 1.12–1.68; p for trend = 0.009), forearm (HR = 1.73; 95% CI 1.09–2.77; p for trend = 0.04), spine (HR = 2.21; 95% CI 1.14–4.31; p for trend = 0.04), and hip fracture (HR = 4.09; 95% CI 1.29–12.96; p for trend = 0.046).
Conclusions: our study is the first to report that high dietary acrylamide may be associated with an increased risk of osteoporotic fractures.
Text
s40520-022-02214-9
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More information
Accepted/In Press date: 27 July 2022
e-pub ahead of print date: 13 August 2022
Published date: October 2022
Additional Information:
Funding Information:
Open access funding provided by Università degli Studi di Palermo within the CRUI-CARE Agreement. Publication costs are supported by the FFR2021 fund of the University of Palermo assigned to Prof. Mario Barbagallo and Nicola Veronese. The OAI is a public–private partnership comprised of five contracts (N01-AR-2-2258; N01-AR-2-2259; N01-AR-2-2260; N01-AR-2-2261; N01-AR-2-2262) funded by the National Institutes of Health, a branch of the Department of Health and Human Services, and conducted by the OAI Study Investigators. Private funding partners include Merck Research Laboratories; Novartis Pharmaceuticals Corporation, GlaxoSmithKline; and Pfizer, Inc. Private sector funding for the OAI is managed by the Foundation for the National Institutes of Health. This manuscript was prepared using an OAI public use data set and does not necessarily reflect the opinions or views of the OAI investigators, the NIH, or the private funding partners.
Publisher Copyright:
© 2022, The Author(s).
Keywords:
Acrylamide, Fracture, Osteoarthritis initiative, Osteoporosis
Identifiers
Local EPrints ID: 469479
URI: http://eprints.soton.ac.uk/id/eprint/469479
ISSN: 1594-0667
PURE UUID: d5a9ad22-c410-48da-923b-ff5ac56e3386
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Date deposited: 15 Sep 2022 16:45
Last modified: 18 Mar 2024 02:47
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Contributors
Author:
Nicola Veronese
Author:
Francesco Bolzetta
Author:
Chiara Cacco
Author:
Alberto Cester
Author:
Lee Smith
Author:
Jacopo Demurtas
Author:
Rene Rizzoli
Author:
Maria Gabriella Caruso
Author:
Maria Notanicola
Author:
Jean-Yves Reginster
Author:
Stefania Maggi
Author:
Mario Barbagallo
Author:
Mike Trott
Author:
Ligia J. Dominguez
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