Integrated analysis reveals the protective mechanism and therapeutic potential of hyperbaric oxygen against pulmonary fibrosis
Integrated analysis reveals the protective mechanism and therapeutic potential of hyperbaric oxygen against pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a dreadful, chronic, and irreversibly progressive disease leading to death with a few effective treatments. Our previous study suggested that repetitive hyperbaric oxygen (HBO) treatment alleviates bleomycin-induced pulmonary fibrosis in mice. Here, we investigated the protective mechanism of HBO treatment against pulmonary fibrosis using an integrated approach. Analyzing publicly available expression data from the mouse model of bleomycin-induced pulmonary fibrosis as well as IPF patients, several potential mechanisms of relevance to IPF pathology were identified, including increased epithelial-to-mesenchymal transition (EMT) and glycolysis. High EMT or glycolysis scores in bronchoalveolar lavage were strong independent predictors of mortality in multivariate analysis. These processes were potentially driven by hypoxia and blocked by HBO treatment. Together, these data support HBO treatment as a viable strategy against pulmonary fibrosis.
Epithelial-mesenchymal transition, Hyperbaricoxygen, Hypoxia, Pulmonary fibrosis, Systematic analysis
Yuan, Yuan
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Qiao, Guoqiang
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Zhou, Jiajiao
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Zhou, Yilu
1878565d-39e6-467d-a027-7320bf4cdaf2
Li, Yali
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Li, Xia
b1864b73-b5f9-458d-b731-b7c9763e3286
Jiang, Zhenglin
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Wang, Yihua
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5 September 2022
Yuan, Yuan
b7b8f296-477c-41c1-b758-27d198cc2925
Qiao, Guoqiang
7cfa217a-1d58-4e45-b6bb-0cf440b93df3
Zhou, Jiajiao
2ec994a3-7ae5-471a-a364-d9fe7431fa4a
Zhou, Yilu
1878565d-39e6-467d-a027-7320bf4cdaf2
Li, Yali
4072e4ad-3a63-4aec-a8b5-b2b782d42e9f
Li, Xia
b1864b73-b5f9-458d-b731-b7c9763e3286
Jiang, Zhenglin
068663cb-e436-44f6-87de-a29c6eeaedb8
Wang, Yihua
f5044a95-60a7-42d2-87d6-5f1f789e3a7e
Yuan, Yuan, Qiao, Guoqiang, Zhou, Jiajiao, Zhou, Yilu, Li, Yali, Li, Xia, Jiang, Zhenglin and Wang, Yihua
(2022)
Integrated analysis reveals the protective mechanism and therapeutic potential of hyperbaric oxygen against pulmonary fibrosis.
Genes and Diseases.
(doi:10.1016/j.gendis.2022.08.012).
Abstract
Idiopathic pulmonary fibrosis (IPF) is a dreadful, chronic, and irreversibly progressive disease leading to death with a few effective treatments. Our previous study suggested that repetitive hyperbaric oxygen (HBO) treatment alleviates bleomycin-induced pulmonary fibrosis in mice. Here, we investigated the protective mechanism of HBO treatment against pulmonary fibrosis using an integrated approach. Analyzing publicly available expression data from the mouse model of bleomycin-induced pulmonary fibrosis as well as IPF patients, several potential mechanisms of relevance to IPF pathology were identified, including increased epithelial-to-mesenchymal transition (EMT) and glycolysis. High EMT or glycolysis scores in bronchoalveolar lavage were strong independent predictors of mortality in multivariate analysis. These processes were potentially driven by hypoxia and blocked by HBO treatment. Together, these data support HBO treatment as a viable strategy against pulmonary fibrosis.
Text
HBO in PF_Genes&Diseases
- Accepted Manuscript
Text
1-s2.0-S2352304222002331-main
- Proof
More information
Accepted/In Press date: 20 August 2022
e-pub ahead of print date: 5 September 2022
Published date: 5 September 2022
Additional Information:
Funding Information:
Yuan Yuan was supported by Natural Science Research of Jiangsu Higher Education Institutions of China (No. 19KJB320002 ), the Science and Technology Project of Nantong City (No. JC2020010 ), and a Research Startup Fund of Nantong University . Yihua Wang was supported by the UK Medical Research Counci l (No. MR/S025480/1 ) and theUK Royal Society (No. IEC∖NSFC∖191030 ). Zhenglin Jiang was supported by the National Natural Science Foundation of China (No. 82171869 and 81671859 ). Xia Li was supported by the Science and Technology Project of Nantong City (No. MS12020019 and JC2021079 ).
Publisher Copyright:
© 2022 Chongqing Medical University
Keywords:
Epithelial-mesenchymal transition, Hyperbaricoxygen, Hypoxia, Pulmonary fibrosis, Systematic analysis
Identifiers
Local EPrints ID: 469556
URI: http://eprints.soton.ac.uk/id/eprint/469556
ISSN: 2352-3042
PURE UUID: 94a76faa-9900-42b7-8a1e-dbdaaab18644
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Date deposited: 20 Sep 2022 16:36
Last modified: 17 Mar 2024 03:39
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Contributors
Author:
Yuan Yuan
Author:
Guoqiang Qiao
Author:
Jiajiao Zhou
Author:
Yali Li
Author:
Xia Li
Author:
Zhenglin Jiang
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