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Individual Molecular Species of Phosphatidy1choline from Fetal and Neonatal Lung

Individual Molecular Species of Phosphatidy1choline from Fetal and Neonatal Lung
Individual Molecular Species of Phosphatidy1choline from Fetal and Neonatal Lung
Measurement of the complete spectrum of individual molecular species of phosphatidylcholine (PC) can potentially provide greater information about the regulation of surfactant metabolism than measurement of total desaturated PC. It facilitates the measurement of the rates of synthesis and catabolism of different PC species in subcellular fractions of the lung [1] , and can allow a more detailed analysis of surfactant PC remodelling in the type II cell and recycling within the alveolus. In this study we have defined the developmental changes in PC species composition that occur in guinea pig and human lung. These methods have been extended to the analysis of PC species in tracheal aspirate samples from preterm human infants.
196-199
Karger
Hall, MA
d3cec7f2-f109-4d05-be5f-86c66b58859e
Hunt, AN
95a3e223-da96-40e7-b47d-27dce014e305
Kelly, FJ
0662f749-2cc5-465a-a4aa-2a6ff64146ac
Normand, I. Colin S.
93c0816b-c5a0-4abf-b4c9-b4cf377aae48
Postle, Anthony
0fa17988-b4a0-4cdc-819a-9ae15c5dad66
von Wichert, P
Müller, B
Hall, MA
d3cec7f2-f109-4d05-be5f-86c66b58859e
Hunt, AN
95a3e223-da96-40e7-b47d-27dce014e305
Kelly, FJ
0662f749-2cc5-465a-a4aa-2a6ff64146ac
Normand, I. Colin S.
93c0816b-c5a0-4abf-b4c9-b4cf377aae48
Postle, Anthony
0fa17988-b4a0-4cdc-819a-9ae15c5dad66
von Wichert, P
Müller, B

Hall, MA, Hunt, AN, Kelly, FJ, Normand, I. Colin S. and Postle, Anthony (1990) Individual Molecular Species of Phosphatidy1choline from Fetal and Neonatal Lung. von Wichert, P and Müller, B (eds.) In Basic Research on Lung Surfactant : 3rd International Symposium on Basic Research on Lung Surfactant, Marburg, September 12-14, 1988. vol. 25, Karger. pp. 196-199 . (doi:10.1159/000417821).

Record type: Conference or Workshop Item (Paper)

Abstract

Measurement of the complete spectrum of individual molecular species of phosphatidylcholine (PC) can potentially provide greater information about the regulation of surfactant metabolism than measurement of total desaturated PC. It facilitates the measurement of the rates of synthesis and catabolism of different PC species in subcellular fractions of the lung [1] , and can allow a more detailed analysis of surfactant PC remodelling in the type II cell and recycling within the alveolus. In this study we have defined the developmental changes in PC species composition that occur in guinea pig and human lung. These methods have been extended to the analysis of PC species in tracheal aspirate samples from preterm human infants.

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Published date: 1 June 1990

Identifiers

Local EPrints ID: 469620
URI: http://eprints.soton.ac.uk/id/eprint/469620
PURE UUID: b2fdd705-4402-4633-a8d7-d800517e08d7
ORCID for AN Hunt: ORCID iD orcid.org/0000-0001-5938-2152
ORCID for Anthony Postle: ORCID iD orcid.org/0000-0001-7361-0756

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Date deposited: 21 Sep 2022 16:50
Last modified: 17 Mar 2024 02:41

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Contributors

Author: MA Hall
Author: AN Hunt ORCID iD
Author: FJ Kelly
Author: I. Colin S. Normand
Author: Anthony Postle ORCID iD
Editor: P von Wichert
Editor: B Müller

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