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Integration of gene maps: chromosome 21

Integration of gene maps: chromosome 21
Integration of gene maps: chromosome 21
Physical, cytogenetic, and genetic data including microsatellite markers and a covering sequence-tagged site (STS) map have been entered into a location database and integrated into a summary map that subsumes a composite physical location, sex-specific genetic locations, cytogenetic and regional assignments, mouse homology, rank, and references. With the omission of 52 loci whose location is known only from cytogenetic assignment to an interval greater than 10 megabases, there are 198 loci in the covering STS map and an additional 145 loci. The physical length is consistent with 11 megabases for 21p and 39 megabases for 21q. With error filtration and allowance for high interference, the genetic length in males corresponds to the chiasma map (54.7 centimorgans), and the genetic length in females is 76.5 centimorgans. The relation between map integration and the STS paradigm is illustrated and …
0027-8424
7210-7214
Lawrence, S
4fcc64a8-9a65-4fa4-a65b-e6f397f41a8f
Collins, Andrew
7daa83eb-0b21-43b2-af1a-e38fb36e2a64
Keats, B.J.
1e85e190-0afd-4831-88e0-0f4153a0614e
Hulten, M
5e9fa871-e652-4106-8e2f-cce7c8758554
Morton, Newton E
c668e2be-074a-4a0a-a2ca-e8f51830ebb7
Lawrence, S
4fcc64a8-9a65-4fa4-a65b-e6f397f41a8f
Collins, Andrew
7daa83eb-0b21-43b2-af1a-e38fb36e2a64
Keats, B.J.
1e85e190-0afd-4831-88e0-0f4153a0614e
Hulten, M
5e9fa871-e652-4106-8e2f-cce7c8758554
Morton, Newton E
c668e2be-074a-4a0a-a2ca-e8f51830ebb7

Lawrence, S, Collins, Andrew, Keats, B.J., Hulten, M and Morton, Newton E (1993) Integration of gene maps: chromosome 21. Proceedings of National Academy of Sciences of the United States of America, 90 (15), 7210-7214. (doi:10.1073/pnas.90.15.721).

Record type: Article

Abstract

Physical, cytogenetic, and genetic data including microsatellite markers and a covering sequence-tagged site (STS) map have been entered into a location database and integrated into a summary map that subsumes a composite physical location, sex-specific genetic locations, cytogenetic and regional assignments, mouse homology, rank, and references. With the omission of 52 loci whose location is known only from cytogenetic assignment to an interval greater than 10 megabases, there are 198 loci in the covering STS map and an additional 145 loci. The physical length is consistent with 11 megabases for 21p and 39 megabases for 21q. With error filtration and allowance for high interference, the genetic length in males corresponds to the chiasma map (54.7 centimorgans), and the genetic length in females is 76.5 centimorgans. The relation between map integration and the STS paradigm is illustrated and …

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Published date: 1 August 1993

Identifiers

Local EPrints ID: 469646
URI: http://eprints.soton.ac.uk/id/eprint/469646
ISSN: 0027-8424
PURE UUID: 6a0f2310-8784-4283-893d-1bc5e52e9853
ORCID for Andrew Collins: ORCID iD orcid.org/0000-0001-7108-0771

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Date deposited: 21 Sep 2022 16:59
Last modified: 17 Mar 2024 02:37

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Contributors

Author: S Lawrence
Author: Andrew Collins ORCID iD
Author: B.J. Keats
Author: M Hulten
Author: Newton E Morton

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