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CEPH Consortium Map of Chromosome 9

CEPH Consortium Map of Chromosome 9
CEPH Consortium Map of Chromosome 9
This paper describes the Centre d'Etude du Polymorphisme Humain (CEPH) consortium linkage map of chromosome 9. A total of 124 markers were typed in the CEPH family DNAs by 14 contributing laboratories; of these, 42 loci are ordered on the map with likelihood support of at least 1000:1. The uniquely placed markers include 31 that can be typed by PCR. A further 28 markers that can be typed by PCR are approximately positioned on the map. Multilocus linkage analysis with CR1-MAP has produced male, female, and sex-averaged maps extending for 176, 237, and 209 cM, respectively, while sex-averaged maps produced with MAPMAKER and the multiple two-point program MAP extended for 170 and 129 cM, respectively. The male map contains only two intervals greater than 10 cM, and the mean genetic distance between the 42 uniquely placed loci is 4.3 cM. However, no markers were available to anchor the map at either telomere or the centromere. The results confirm the high level of interference suggested by chiasma maps of chromosome 9. Detailed meiotic breakpoints for three of the families are shown. These can be used to provide rapid placement of any new marker without the need for statistical analysis.
0888-7543
203-214
Attwood, J.
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Chiano, M.
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Collins, A.
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Donis-keller, H.
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Dracopoli, N.
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Fountain, J.
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Falk, C.
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Goudie, D.
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Gusella, J.
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Haines, J.
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Armour, J.a.l.
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Jeffreys, A.j.
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Kwiatkowski, D.
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Lathrop, M.
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Matise, T.
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Northrup, H.
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Pericak-vance, M.a.
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Phillips, J.
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Retief, A.
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Robson, E.
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Shields, D.
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Slaugenhaupt, S.
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Vergnaud, G.
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Weber, J.
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Weissenbach, J.
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White, R.
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Yates, J.
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Povey, S.
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Attwood, J.
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Chiano, M.
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Collins, A.
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Donis-keller, H.
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Dracopoli, N.
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Fountain, J.
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Falk, C.
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Goudie, D.
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Gusella, J.
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Haines, J.
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Armour, J.a.l.
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Jeffreys, A.j.
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Kwiatkowski, D.
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Lathrop, M.
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Matise, T.
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Northrup, H.
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Pericak-vance, M.a.
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Phillips, J.
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Retief, A.
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Robson, E.
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Shields, D.
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Slaugenhaupt, S.
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Vergnaud, G.
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Weber, J.
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Weissenbach, J.
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White, R.
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Yates, J.
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Povey, S.
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Attwood, J., Chiano, M., Collins, A., Donis-keller, H., Dracopoli, N., Fountain, J., Falk, C., Goudie, D., Gusella, J., Haines, J., Armour, J.a.l., Jeffreys, A.j., Kwiatkowski, D., Lathrop, M., Matise, T., Northrup, H., Pericak-vance, M.a., Phillips, J., Retief, A., Robson, E., Shields, D., Slaugenhaupt, S., Vergnaud, G., Weber, J., Weissenbach, J., White, R., Yates, J. and Povey, S. (1994) CEPH Consortium Map of Chromosome 9. Genomics, 19 (2), 203-214. (doi:10.1006/geno.1994.1049).

Record type: Article

Abstract

This paper describes the Centre d'Etude du Polymorphisme Humain (CEPH) consortium linkage map of chromosome 9. A total of 124 markers were typed in the CEPH family DNAs by 14 contributing laboratories; of these, 42 loci are ordered on the map with likelihood support of at least 1000:1. The uniquely placed markers include 31 that can be typed by PCR. A further 28 markers that can be typed by PCR are approximately positioned on the map. Multilocus linkage analysis with CR1-MAP has produced male, female, and sex-averaged maps extending for 176, 237, and 209 cM, respectively, while sex-averaged maps produced with MAPMAKER and the multiple two-point program MAP extended for 170 and 129 cM, respectively. The male map contains only two intervals greater than 10 cM, and the mean genetic distance between the 42 uniquely placed loci is 4.3 cM. However, no markers were available to anchor the map at either telomere or the centromere. The results confirm the high level of interference suggested by chiasma maps of chromosome 9. Detailed meiotic breakpoints for three of the families are shown. These can be used to provide rapid placement of any new marker without the need for statistical analysis.

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More information

Published date: 15 January 1994

Identifiers

Local EPrints ID: 469652
URI: http://eprints.soton.ac.uk/id/eprint/469652
ISSN: 0888-7543
PURE UUID: 18947a73-0510-45e8-af86-ebcc3ac8d1aa
ORCID for A. Collins: ORCID iD orcid.org/0000-0001-7108-0771

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Date deposited: 21 Sep 2022 17:01
Last modified: 17 Mar 2024 02:37

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Contributors

Author: J. Attwood
Author: M. Chiano
Author: A. Collins ORCID iD
Author: H. Donis-keller
Author: N. Dracopoli
Author: J. Fountain
Author: C. Falk
Author: D. Goudie
Author: J. Gusella
Author: J. Haines
Author: J.a.l. Armour
Author: A.j. Jeffreys
Author: D. Kwiatkowski
Author: M. Lathrop
Author: T. Matise
Author: H. Northrup
Author: M.a. Pericak-vance
Author: J. Phillips
Author: A. Retief
Author: E. Robson
Author: D. Shields
Author: S. Slaugenhaupt
Author: G. Vergnaud
Author: J. Weber
Author: J. Weissenbach
Author: R. White
Author: J. Yates
Author: S. Povey

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