Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk
Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk
We mapped a high-penetrance gene (CRAC1; also known as HMPS) associated with colorectal cancer (CRC) in the Ashkenazi population to a 0.6-Mb region on chromosome 15 containing SCG5 (also known as SGNE1), GREM1 and FMN1. We hypothesized that the CRAC1 locus harbored low-penetrance variants that increased CRC risk in the general population. In a large series of colorectal cancer cases and controls, SNPs near GREM1 and SCG5 were strongly associated with increased CRC risk (for rs4779584, P = 4.44 × 10−14).
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Jaeger, E
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Webb, E
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Howarth, K
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Carvajal-Carmona, L
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Rowan, A
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Broderick, P
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Walther, A
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Spain, S
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Pittman, A
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Kemp, Z
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Sullivan, K
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Heinimann, K
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Lubbe, S
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Tomlinson, I
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1 January 2008
Jaeger, E
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Webb, E
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Howarth, K
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Carvajal-Carmona, L
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Rowan, A
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Broderick, P
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Walther, A
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Spain, S
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Pittman, A
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Kemp, Z
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Sullivan, K
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Heinimann, K
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Lubbe, S
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Tomlinson, I
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Jaeger, E, Webb, E, Howarth, K, Carvajal-Carmona, L, Rowan, A, Broderick, P, Walther, A, Spain, S, Pittman, A, Kemp, Z, Sullivan, K, Heinimann, K, Lubbe, S and Tomlinson, I
(2008)
Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk.
Nature Genetics, 40, .
(doi:10.1038/ng.2007.41).
Abstract
We mapped a high-penetrance gene (CRAC1; also known as HMPS) associated with colorectal cancer (CRC) in the Ashkenazi population to a 0.6-Mb region on chromosome 15 containing SCG5 (also known as SGNE1), GREM1 and FMN1. We hypothesized that the CRAC1 locus harbored low-penetrance variants that increased CRC risk in the general population. In a large series of colorectal cancer cases and controls, SNPs near GREM1 and SCG5 were strongly associated with increased CRC risk (for rs4779584, P = 4.44 × 10−14).
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e-pub ahead of print date: 16 December 2007
Published date: 1 January 2008
Additional Information:
Copyright © 2007, Nature Publishing Group
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Local EPrints ID: 469698
URI: http://eprints.soton.ac.uk/id/eprint/469698
ISSN: 1061-4036
PURE UUID: f4334eef-d13a-45b2-bfbd-d5facc808631
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Date deposited: 22 Sep 2022 16:38
Last modified: 16 Mar 2024 18:07
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Author:
E Jaeger
Author:
E Webb
Author:
K Howarth
Author:
L Carvajal-Carmona
Author:
A Rowan
Author:
P Broderick
Author:
A Walther
Author:
S Spain
Author:
A Pittman
Author:
Z Kemp
Author:
K Sullivan
Author:
K Heinimann
Author:
S Lubbe
Author:
I Tomlinson
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