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A SARS-Cov-2 sensor based on upconversion nanoparticles and graphene oxide

A SARS-Cov-2 sensor based on upconversion nanoparticles and graphene oxide
A SARS-Cov-2 sensor based on upconversion nanoparticles and graphene oxide

Since the beginning of the COVID-19 pandemic, there has been an increased need for the development of novel diagnostic solutions that can accurately and rapidly detect SARS-CoV-2 infection. In this work, we demonstrate the targeting of viral oligonucleotide markers within minutes without the requirement of a polymerase chain reaction (PCR) amplification step via the use of oligonucleotide-coated upconversion nanoparticles (UCNPs) and graphene oxide (GO).

2046-2069
18445-18449
Alexaki, Konstantina
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Kyriazi, Maria Eleni
3cfe9662-4e7f-49bc-b707-ccc2b4da6b09
Greening, Joshua
e74bf8ad-15c9-49cd-848d-d7e392435c4e
Taemaitree, Lapatrada
c069b3ef-6d34-4a85-a351-2576fb01af64
El-Sagheer, Afaf H.
05b8295a-64ad-4fdf-ad57-c34934a46c04
Brown, Tom
a64aae36-bb30-42df-88a2-11be394e8c89
Zhang, Xunli
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Muskens, Otto L.
2284101a-f9ef-4d79-8951-a6cda5bfc7f9
Kanaras, Antonios G.
667ecfdc-7647-4bd8-be03-a47bf32504c7
Alexaki, Konstantina
4eb3b612-8a61-41cc-855e-7ccf917310f7
Kyriazi, Maria Eleni
3cfe9662-4e7f-49bc-b707-ccc2b4da6b09
Greening, Joshua
e74bf8ad-15c9-49cd-848d-d7e392435c4e
Taemaitree, Lapatrada
c069b3ef-6d34-4a85-a351-2576fb01af64
El-Sagheer, Afaf H.
05b8295a-64ad-4fdf-ad57-c34934a46c04
Brown, Tom
a64aae36-bb30-42df-88a2-11be394e8c89
Zhang, Xunli
d7cf1181-3276-4da1-9150-e212b333abb1
Muskens, Otto L.
2284101a-f9ef-4d79-8951-a6cda5bfc7f9
Kanaras, Antonios G.
667ecfdc-7647-4bd8-be03-a47bf32504c7

Alexaki, Konstantina, Kyriazi, Maria Eleni, Greening, Joshua, Taemaitree, Lapatrada, El-Sagheer, Afaf H., Brown, Tom, Zhang, Xunli, Muskens, Otto L. and Kanaras, Antonios G. (2022) A SARS-Cov-2 sensor based on upconversion nanoparticles and graphene oxide. RSC Advances, 12 (29), 18445-18449. (doi:10.1039/d2ra03599e).

Record type: Article

Abstract

Since the beginning of the COVID-19 pandemic, there has been an increased need for the development of novel diagnostic solutions that can accurately and rapidly detect SARS-CoV-2 infection. In this work, we demonstrate the targeting of viral oligonucleotide markers within minutes without the requirement of a polymerase chain reaction (PCR) amplification step via the use of oligonucleotide-coated upconversion nanoparticles (UCNPs) and graphene oxide (GO).

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Accepted/In Press date: 22 June 2022
Published date: 22 June 2022
Additional Information: Funding Information: A. G. K. and J. G. would like to thank the University of Southampton for a DTP PhD Scholarship. K. A. would like to thank the School of Physics and Astronomy for a Mayflower studentship. A. G. K. and M. E. K. would like to thank funding from BBSRC (Grant No. BB/N021150/1).

Identifiers

Local EPrints ID: 469901
URI: http://eprints.soton.ac.uk/id/eprint/469901
ISSN: 2046-2069
PURE UUID: a8fffb52-b457-4619-b08d-6bdd782fce16
ORCID for Konstantina Alexaki: ORCID iD orcid.org/0000-0002-8702-2696
ORCID for Afaf H. El-Sagheer: ORCID iD orcid.org/0000-0001-8706-1292
ORCID for Xunli Zhang: ORCID iD orcid.org/0000-0002-4375-1571
ORCID for Otto L. Muskens: ORCID iD orcid.org/0000-0003-0693-5504
ORCID for Antonios G. Kanaras: ORCID iD orcid.org/0000-0002-9847-6706

Catalogue record

Date deposited: 28 Sep 2022 16:43
Last modified: 01 Feb 2023 02:39

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Contributors

Author: Konstantina Alexaki ORCID iD
Author: Maria Eleni Kyriazi
Author: Joshua Greening
Author: Lapatrada Taemaitree
Author: Afaf H. El-Sagheer ORCID iD
Author: Tom Brown
Author: Xunli Zhang ORCID iD
Author: Otto L. Muskens ORCID iD

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