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Fabrication and characterization of porous poly(lactic-co-glycolic acid) (PLGA) microspheres for use as a drug delivery system

Fabrication and characterization of porous poly(lactic-co-glycolic acid) (PLGA) microspheres for use as a drug delivery system
Fabrication and characterization of porous poly(lactic-co-glycolic acid) (PLGA) microspheres for use as a drug delivery system
In this work, Simvastatin (SIM) loaded porous poly(lactic-co-glycolic acid) (PLGA) microspheres were fabricated using the W/O/W1/W2 double emulsion and solvent evaporation method. The optimal conditions for fabricating porous PLGA microspheres were determined to be 20% distilled water (v/v), 10% PLGA (m/v), and a 4:1 ratio of internal polyvinyl alcohol (PVA) to dichloromethane (DCM). The pores size distribution of porous PLGA microspheres was varied from 0.01 to 40 μm, while their particle displayed a bimodal size distribution that had two diameter peaks at around 100 μm and 500 μm. The SIM encapsulation efficacy was found to be very high with a yield near 80% and the porous PLGA microspheres showed the excellent biocompatibility. In addition, the drug release profile was found to be significantly different from a temporal basis. Base on the combined results of this study, SIM loaded PLGA microspheres holds great promise for use in biomedical applications, especially in drug delivery system or tissue regeneration.
0022-2461
2510–2517
Bao, Trinh-Quang
ce5afcf3-2eb6-4569-a68c-c62c002e8fc3
Hiep, Nguyen-Thi
fb9817a8-0d3e-47ef-b5b5-4e4aee8f7934
Kim, Yang-Hee
de0d641b-c2cb-4e73-9ae2-e20d33689f5d
Yang, Hun-Mo
99e6dae0-64df-4f5d-b5e6-fc1516f26885
Lee, Byong-Taek
f9db3ab3-d370-4639-adba-1a8af747163c
Bao, Trinh-Quang
ce5afcf3-2eb6-4569-a68c-c62c002e8fc3
Hiep, Nguyen-Thi
fb9817a8-0d3e-47ef-b5b5-4e4aee8f7934
Kim, Yang-Hee
de0d641b-c2cb-4e73-9ae2-e20d33689f5d
Yang, Hun-Mo
99e6dae0-64df-4f5d-b5e6-fc1516f26885
Lee, Byong-Taek
f9db3ab3-d370-4639-adba-1a8af747163c

Bao, Trinh-Quang, Hiep, Nguyen-Thi, Kim, Yang-Hee, Yang, Hun-Mo and Lee, Byong-Taek (2011) Fabrication and characterization of porous poly(lactic-co-glycolic acid) (PLGA) microspheres for use as a drug delivery system. Journal of Materials Science, 46 (8), 2510–2517. (doi:10.1007/s10853-010-5101-4).

Record type: Article

Abstract

In this work, Simvastatin (SIM) loaded porous poly(lactic-co-glycolic acid) (PLGA) microspheres were fabricated using the W/O/W1/W2 double emulsion and solvent evaporation method. The optimal conditions for fabricating porous PLGA microspheres were determined to be 20% distilled water (v/v), 10% PLGA (m/v), and a 4:1 ratio of internal polyvinyl alcohol (PVA) to dichloromethane (DCM). The pores size distribution of porous PLGA microspheres was varied from 0.01 to 40 μm, while their particle displayed a bimodal size distribution that had two diameter peaks at around 100 μm and 500 μm. The SIM encapsulation efficacy was found to be very high with a yield near 80% and the porous PLGA microspheres showed the excellent biocompatibility. In addition, the drug release profile was found to be significantly different from a temporal basis. Base on the combined results of this study, SIM loaded PLGA microspheres holds great promise for use in biomedical applications, especially in drug delivery system or tissue regeneration.

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More information

Accepted/In Press date: 19 November 2010
Published date: 15 April 2011
Additional Information: This work was supported by Mid-career Research Program through NRI grant funded by the MEST (2009-0092808) and Prof. Hun Mo Yang who was supported by Soonchunhyang University 2009 research year program.

Identifiers

Local EPrints ID: 470131
URI: http://eprints.soton.ac.uk/id/eprint/470131
ISSN: 0022-2461
PURE UUID: 05632929-6a4c-4ff9-8b82-62f54056c379
ORCID for Yang-Hee Kim: ORCID iD orcid.org/0000-0002-5312-3448

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Date deposited: 03 Oct 2022 17:04
Last modified: 04 Oct 2022 01:48

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Contributors

Author: Trinh-Quang Bao
Author: Nguyen-Thi Hiep
Author: Yang-Hee Kim ORCID iD
Author: Hun-Mo Yang
Author: Byong-Taek Lee

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