Changes in serotype prevalence of Streptococcus pneumoniae in Southampton, UK between 2006 and 2018

Accepted/In Press date: 27 July 2022

Published date: 3 August 2022

Additional Information: Funding Information: This work was supported by Pfizer as an investigator-led research grant. Funding for whole genome sequencing was provided by the Wellcome Sanger Institute. Funding Information: DWC was a post-doctoral researcher on GSK funded projects in 2014/15, and currently receives grant support from Pfizer and the National Institute for Health via the NIHR Southampton Biomedical Research Centre. SNF receives support from the National Institute for Health Research funding via the NIHR Southampton Wellcome Trust Clinical Research Facility and the NIHR Southampton Biomedical Research Centre. SNF and SCC act as principal investigators for clinical trials and other studies conducted on behalf of University Hospital Southampton NHS Foundation Trust/University of Southampton that are sponsored by vaccine manufacturers. No personal payments are received from them. SNF, JMJ and SCC have participated in advisory boards for vaccine manufacturers but receive no personal payments for this work. SNF, SCC and JMJ have received financial assistance from vaccine manufacturers to attend conferences. All grants and honoraria are paid into accounts within the respective NHS Trusts or Universities, or to independent charities. RAG, VTD and JJ received PhD studentships via the University of Southampton from Pfizer. RAG received post-doctoral support in 2012 on a GSK funded research project via the University of Southampton. KLO received PhD studentship support from GSK, again via the University of Southampton. All other authors have no conflicts of interest. Funding Information: We would like to acknowledge the support of our technical colleagues, namely Rebecca Anderson, Denise E. Morris, Stephen Gomer and Emily J. Dineen in the collection and processing of samples for the study. We are grateful to staff in both the Pathogen Genomics team and those associated with the Global Pneumococcal Sequencing Project at the WSI for their support in genome sequencing of collected isolates. We are indebted to staff at the NIHR Southampton Wellcome Trust Clinical Research Facility for their assistance in the collection of samples and to staff at Public Health England for swab processing between 2006/07 and 2011/12. The authors also acknowledge the use of the IRIDIS High Performance Computing Facility, and associated support services at the University of Southampton, in the completion of this work. Finally, we acknowledge both the guardians and participants without whom this study would not have been possible. Publisher Copyright: © 2022, The Author(s).

Keywords: Carrier State/epidemiology, Child, Child, Preschool, Cross-Sectional Studies, Humans, Infant, Nasopharynx, Pneumococcal Infections/prevention & control, Pneumococcal Vaccines, Prevalence, Serogroup, Streptococcus pneumoniae/genetics, United Kingdom/epidemiology, Vaccines, Conjugate

Local EPrints ID: 470145

URI: http://eprints.soton.ac.uk/id/eprint/470145

DOI: doi:10.1038/s41598-022-17600-6

ISSN: 2045-2322

PURE UUID: 5a5dde5f-2cf8-4c75-a924-52ffc0cc8403

ORCID for David W. Cleary: orcid.org/0000-0003-4533-0700

ORCID for Saul N Faust: orcid.org/0000-0003-3410-7642

ORCID for Stuart C. Clarke: orcid.org/0000-0002-7009-1548

Date deposited: 04 Oct 2022 16:36

Last modified: 17 Mar 2024 07:28