Fabrication and material properties of fibrous PHBV scaffolds depending on the cross-ply angle for tissue engineering

Kim, Y.-H., Min, Y.-K. and Lee, B.-T. (2012) Fabrication and material properties of fibrous PHBV scaffolds depending on the cross-ply angle for tissue engineering. Journal of Biomaterials Applications, 27 (4), 457-468. (doi:10.1177/0885328211411956).

Record type: Article

Abstract

Fibrous PHBV cross-ply scaffolds were fabricated using the electrospinning technique. The electrospun fibers were arranged depending on angles of alignment, which were 180°, 90°, 60°, and 45°. The stress and strain values of the fibrous PHBV cross-ply scaffolds increased as the cross-ply angle increased. At 180°, the strength and strain values of the fibers depended on tensile loading directions. At an alignment of 90°, the PHBV scaffolds had a stress value of 3.5 MPa, which was more than two times higher than the random structure. The cell morphology and proliferation of L-929 cells was strongly dependant on the fiber alignment and the best results were observed when the angle alignment was high. The results of this study showed that the cross-ply structure of the PHBV scaffold affected not only the cell adhesion and spreading properties but also dictated the mechanical properties, which were dependent on the angles of alignment.

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