Targeting the epidermal growth factor receptor for therapy of carcinomas
Targeting the epidermal growth factor receptor for therapy of carcinomas
As a group, the carcinomas represent a substantial proportion of all human malignancies, but, with relatively few exceptions, current treatments are ineffective. Modification of existing chemotherapeutic agents has not led to significant improvements in the survival of carcinoma patients, and development of new therapeutic strategies is imperative. It is now becoming apparent that activation of the epidermal growth factor receptor (EGF-R) has much wider implications than a straightforward stimulation of cell division. The pleiotropic effects of EGF-R signalling may influence tumour behaviour and the response of carcinomas to treatment; these are important considerations for the development of new therapies that aim to exploit the expression or modulate the function of the EGF-R in these tumours.
cancer, epidermal growth factor receptor, growth factors, proliferation, therapy
1101-1110
Davies, Donna E.
7de8fdc7-3640-4e3a-aa91-d0e03f990c38
Chamberlin, Stephen G.
ecb947dd-c59e-4c1d-b1f5-60aff91fbeb0
3 May 1996
Davies, Donna E.
7de8fdc7-3640-4e3a-aa91-d0e03f990c38
Chamberlin, Stephen G.
ecb947dd-c59e-4c1d-b1f5-60aff91fbeb0
Davies, Donna E. and Chamberlin, Stephen G.
(1996)
Targeting the epidermal growth factor receptor for therapy of carcinomas.
Biochemical Pharmacology, 51 (9), .
(doi:10.1016/0006-2952(95)02232-5).
Abstract
As a group, the carcinomas represent a substantial proportion of all human malignancies, but, with relatively few exceptions, current treatments are ineffective. Modification of existing chemotherapeutic agents has not led to significant improvements in the survival of carcinoma patients, and development of new therapeutic strategies is imperative. It is now becoming apparent that activation of the epidermal growth factor receptor (EGF-R) has much wider implications than a straightforward stimulation of cell division. The pleiotropic effects of EGF-R signalling may influence tumour behaviour and the response of carcinomas to treatment; these are important considerations for the development of new therapies that aim to exploit the expression or modulate the function of the EGF-R in these tumours.
This record has no associated files available for download.
More information
Published date: 3 May 1996
Keywords:
cancer, epidermal growth factor receptor, growth factors, proliferation, therapy
Identifiers
Local EPrints ID: 470303
URI: http://eprints.soton.ac.uk/id/eprint/470303
ISSN: 0006-2952
PURE UUID: 6cafbe78-6805-4028-a03d-7fa0ecaebd65
Catalogue record
Date deposited: 06 Oct 2022 16:30
Last modified: 17 Mar 2024 02:33
Export record
Altmetrics
Contributors
Author:
Stephen G. Chamberlin
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
