Phospholipid composition of neonatal guinea pig liver and plasma: Effect of postnatal food restriction
Phospholipid composition of neonatal guinea pig liver and plasma: Effect of postnatal food restriction
Preterm guinea pigs were delivered on day 65 of gestation (term=68 d) and were allowed either free or restricted access to food for the subsequent 48 h. Plasma phosphatidylcholine (PC) concentration increased postnatally from 190 (range 144–307) to 751 (426–1039) and 883 (758–977) μM for fed and starved pups, respectively. Plasma PC composition in both groups of pups was characterized by selective and equivalent relative increases to individual molecular species containing 18∶0 at thesn-1 position. Hepatic PC concentration increased from 6.75 (5.41–8.20) to 8.65 (6.54–10.63) and 9.23 (8.18–10.17) μmol/g for fed and starved pups, respectively, and, under all conditions, hepatic PC molecular composition closely mirrored that of plasma PC. These results support the hypothesis that the molecular species composition of plasma PC for the guinea pig in the immediate postnatal period is determined largely by the composition of the hepatic PC pool destined for lipoprotein secretion. Hepatic PC composition and concentration of the starved neonatal guinea pig were maintained independently of any dietary nutrient intake, at the expense of mobilization of extra hepatic lipid reserves. While this adaptive mechanism has inherent limited survival potential in neonatal starvation, it has implications for studies measuring plasma phospholipid fatty acid compositions as biochemical markers of dietary fat intake in preterm infants.
489-495
Hunt, A.N.
95a3e223-da96-40e7-b47d-27dce014e305
Burdge, G.C.
09d60a07-8ca1-4351-9bf1-de6ffcfb2159
Postle, A.D.
0fa17988-b4a0-4cdc-819a-9ae15c5dad66
1 May 1996
Hunt, A.N.
95a3e223-da96-40e7-b47d-27dce014e305
Burdge, G.C.
09d60a07-8ca1-4351-9bf1-de6ffcfb2159
Postle, A.D.
0fa17988-b4a0-4cdc-819a-9ae15c5dad66
Hunt, A.N., Burdge, G.C. and Postle, A.D.
(1996)
Phospholipid composition of neonatal guinea pig liver and plasma: Effect of postnatal food restriction.
Lipids, 31 (5), .
(doi:10.1007/BF02522642).
Abstract
Preterm guinea pigs were delivered on day 65 of gestation (term=68 d) and were allowed either free or restricted access to food for the subsequent 48 h. Plasma phosphatidylcholine (PC) concentration increased postnatally from 190 (range 144–307) to 751 (426–1039) and 883 (758–977) μM for fed and starved pups, respectively. Plasma PC composition in both groups of pups was characterized by selective and equivalent relative increases to individual molecular species containing 18∶0 at thesn-1 position. Hepatic PC concentration increased from 6.75 (5.41–8.20) to 8.65 (6.54–10.63) and 9.23 (8.18–10.17) μmol/g for fed and starved pups, respectively, and, under all conditions, hepatic PC molecular composition closely mirrored that of plasma PC. These results support the hypothesis that the molecular species composition of plasma PC for the guinea pig in the immediate postnatal period is determined largely by the composition of the hepatic PC pool destined for lipoprotein secretion. Hepatic PC composition and concentration of the starved neonatal guinea pig were maintained independently of any dietary nutrient intake, at the expense of mobilization of extra hepatic lipid reserves. While this adaptive mechanism has inherent limited survival potential in neonatal starvation, it has implications for studies measuring plasma phospholipid fatty acid compositions as biochemical markers of dietary fat intake in preterm infants.
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e-pub ahead of print date: 1 May 1996
Published date: 1 May 1996
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Local EPrints ID: 470373
URI: http://eprints.soton.ac.uk/id/eprint/470373
ISSN: 0024-4201
PURE UUID: 5ddf79bb-cac1-4d80-a213-29bf9a7c4764
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Date deposited: 07 Oct 2022 16:34
Last modified: 17 Mar 2024 02:41
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A.N. Hunt
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