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Subretinal drusenoid deposits as a biomarker of age-related macular degeneration progression via reduction of the choroidal vascularity index

Subretinal drusenoid deposits as a biomarker of age-related macular degeneration progression via reduction of the choroidal vascularity index
Subretinal drusenoid deposits as a biomarker of age-related macular degeneration progression via reduction of the choroidal vascularity index
Background/Objectives: this study aimed to analyse the role of the choroid in early age-related macular degeneration (AMD) by analysing choroidal vascularity index (CVI) in pure cohorts of patients with subretinal drusenoid deposits (SDD) or conventional drusen (CD).

Subjects/Methods: this was an observational cross-sectional study. Comprehensive ophthalmologic examination and multimodal imaging including fundus photography, autofluorescence, near infrared reflectance, and spectral domain optical coherence tomography (SDOCT) was performed. CVI processing was performed on a foveal horizontal SDOCT scan with binarization using Image J Image software and calculated as the ratio between luminal area (LA) and total area (TA).

Results: sixty-nine eyes of 69 participants were included; 23 eyes with SDD alone, 22 eyes with CD alone, and 24 control eyes of healthy age-matched subjects. CVI was significantly reduced in the SDD and CD group compared to controls (p = 0.0001). Post-hoc analysis revealed a significant reduction of CVI in the SDD versus the control group (p = 0.0002), in the CD versus the control group (p = 0.001), and in the SDD versus the CD group (p = 0.006). Covariance analysis showed a significant difference of LA (p = 0.033) but no significant difference of TA (p = 0.106) between the three groups. Direct comparison between CD and SDD showed a significant reduction of LA and TA in the SDD group.

Conclusions: CVI may have prognostic implications in early AMD. SDD is a biomarker of AMD progression and the mechanism for this could be via reduction of the CVI.
0950-222X
Abdolrahimzadeh, Solmaz
3aa4d304-cb8b-4830-8945-49261ac74993
Di Pippo, Mariachiara
1993f609-c150-4e15-832b-4a1b7821574b
Sordi, Edoardo
34cb65d7-180f-45e1-8432-1093565661de
Cusato, Mattia
24aed837-d785-485d-8190-2a3f647885cb
Lotery, Andrew
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514
Abdolrahimzadeh, Solmaz
3aa4d304-cb8b-4830-8945-49261ac74993
Di Pippo, Mariachiara
1993f609-c150-4e15-832b-4a1b7821574b
Sordi, Edoardo
34cb65d7-180f-45e1-8432-1093565661de
Cusato, Mattia
24aed837-d785-485d-8190-2a3f647885cb
Lotery, Andrew
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514

Abdolrahimzadeh, Solmaz, Di Pippo, Mariachiara, Sordi, Edoardo, Cusato, Mattia and Lotery, Andrew (2022) Subretinal drusenoid deposits as a biomarker of age-related macular degeneration progression via reduction of the choroidal vascularity index. Eye. (doi:10.1038/s41433-022-02134-y).

Record type: Article

Abstract

Background/Objectives: this study aimed to analyse the role of the choroid in early age-related macular degeneration (AMD) by analysing choroidal vascularity index (CVI) in pure cohorts of patients with subretinal drusenoid deposits (SDD) or conventional drusen (CD).

Subjects/Methods: this was an observational cross-sectional study. Comprehensive ophthalmologic examination and multimodal imaging including fundus photography, autofluorescence, near infrared reflectance, and spectral domain optical coherence tomography (SDOCT) was performed. CVI processing was performed on a foveal horizontal SDOCT scan with binarization using Image J Image software and calculated as the ratio between luminal area (LA) and total area (TA).

Results: sixty-nine eyes of 69 participants were included; 23 eyes with SDD alone, 22 eyes with CD alone, and 24 control eyes of healthy age-matched subjects. CVI was significantly reduced in the SDD and CD group compared to controls (p = 0.0001). Post-hoc analysis revealed a significant reduction of CVI in the SDD versus the control group (p = 0.0002), in the CD versus the control group (p = 0.001), and in the SDD versus the CD group (p = 0.006). Covariance analysis showed a significant difference of LA (p = 0.033) but no significant difference of TA (p = 0.106) between the three groups. Direct comparison between CD and SDD showed a significant reduction of LA and TA in the SDD group.

Conclusions: CVI may have prognostic implications in early AMD. SDD is a biomarker of AMD progression and the mechanism for this could be via reduction of the CVI.

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EYE_REVISION_36675_1_merged_1651225757_copy - Accepted Manuscript
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Accepted/In Press date: 9 June 2022
e-pub ahead of print date: 23 June 2022
Published date: 23 June 2022
Additional Information: Funding Information: The work was done at the Regional Scientific and Educational Mathematical Center of Southern Federal University with the support of the Ministry of Education and Science of Russia, Agreement No. 075-02-2022-893. Alexey Karapetyants is partially supported by the Russian Foundation for Fundamental Research, Project 20-51-46003-a. Publisher Copyright: © 2022, The Author(s), under exclusive licence to The Royal College of Ophthalmologists.

Identifiers

Local EPrints ID: 470488
URI: http://eprints.soton.ac.uk/id/eprint/470488
ISSN: 0950-222X
PURE UUID: ec70ad0a-8684-4529-b6e6-3c93eb1e0882
ORCID for Andrew Lotery: ORCID iD orcid.org/0000-0001-5541-4305

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Date deposited: 11 Oct 2022 16:51
Last modified: 23 Jan 2023 05:01

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Contributors

Author: Solmaz Abdolrahimzadeh
Author: Mariachiara Di Pippo
Author: Edoardo Sordi
Author: Mattia Cusato
Author: Andrew Lotery ORCID iD

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