The biofilm life cycle: expanding the conceptual model of biofilm formation
The biofilm life cycle: expanding the conceptual model of biofilm formation
Bacterial biofilms are often defined as communities of surface attached bacteria. Biofilms are typically depicted with a classic mushroom-shaped structure that is a characteristic of Pseudomonas aeruginosa. However, it has become evident that this is not how all biofilms develop, especially in vivo and in the environment where biofilms often are observed as none surface attached aggregates. In this Review we describe the rationale behind the 5-step model and why it fails to capture many aspects of bacterial biofilm physiology, and aim to present an expanded developmental model for biofilm formation that is flexible enough to include all the diverse scenarios and microenvironments where biofilms are formed. With this new expanded inclusive model, we introduce a common platform for developing our understanding of biofilms and antibiofilm strategies that can be tailored to the microenvironment that is being investigated.
608 - 620
Sauer, Karin
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Stoodley, Paul
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Goeres, Darla M.
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Hall-stoodley, Luanne
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Burmolle, Mette
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Stewart, Philip S.
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Bjarnsholt, Thomas
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Sauer, Karin
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Stoodley, Paul
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Goeres, Darla M.
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Hall-stoodley, Luanne
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Burmolle, Mette
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Stewart, Philip S.
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Bjarnsholt, Thomas
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Sauer, Karin, Stoodley, Paul, Goeres, Darla M., Hall-stoodley, Luanne, Burmolle, Mette, Stewart, Philip S. and Bjarnsholt, Thomas
(2022)
The biofilm life cycle: expanding the conceptual model of biofilm formation.
Nature Reviews Microbiology, 20, .
Abstract
Bacterial biofilms are often defined as communities of surface attached bacteria. Biofilms are typically depicted with a classic mushroom-shaped structure that is a characteristic of Pseudomonas aeruginosa. However, it has become evident that this is not how all biofilms develop, especially in vivo and in the environment where biofilms often are observed as none surface attached aggregates. In this Review we describe the rationale behind the 5-step model and why it fails to capture many aspects of bacterial biofilm physiology, and aim to present an expanded developmental model for biofilm formation that is flexible enough to include all the diverse scenarios and microenvironments where biofilms are formed. With this new expanded inclusive model, we introduce a common platform for developing our understanding of biofilms and antibiofilm strategies that can be tailored to the microenvironment that is being investigated.
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Accepted/In Press date: 21 June 2022
e-pub ahead of print date: 3 August 2022
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Local EPrints ID: 470550
URI: http://eprints.soton.ac.uk/id/eprint/470550
ISSN: 1740-1526
PURE UUID: d58fe310-cfaa-4e27-ac39-0f1cf79209f7
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Date deposited: 12 Oct 2022 16:49
Last modified: 17 Mar 2024 07:31
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Contributors
Author:
Karin Sauer
Author:
Darla M. Goeres
Author:
Luanne Hall-stoodley
Author:
Mette Burmolle
Author:
Philip S. Stewart
Author:
Thomas Bjarnsholt
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